INT172021

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Context Info
Confidence 0.18
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.93
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (Hspa5) endoplasmic reticulum (Hspa5) nucleus (Hspa5)
response to stress (Hspa5)
Anatomy Link Frequency
reticulum 1
Hspa5 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 94 98.12 Very High Very High Very High
Arthritis 6 43.84 Quite Low
Glutamate 31 5.00 Very Low Very Low Very Low
Glutamate receptor 20 5.00 Very Low Very Low Very Low
antagonist 9 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
potassium channel 3 5.00 Very Low Very Low Very Low
Hippocampus 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 3 99.60 Very High Very High Very High
Rheumatoid Arthritis 94 98.12 Very High Very High Very High
Disease 29 88.96 High High
Shock 1 70.96 Quite High
Intellectual Impairment 3 53.92 Quite High
Arthritis 7 43.84 Quite Low
Mycobacterium Infection 2 37.24 Quite Low
Death 1 37.12 Quite Low
Trepenoma Infection 1 36.24 Quite Low
Communicable Diseases 4 35.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BiP is a ubiquitously expressed chaperone protein predominantly localized in the endoplasmic reticulum.
Localization (localized) of BiP in reticulum
1) Confidence 0.18 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.68 Pain Relevance 0.20
In fact, stargazin, AMPA-Rs, and stress response chaperone BiP co-localize in the ER, suggesting a possible role of stargazin in assisting AMPA-R folding under stress conditions [189].
Localization (localize) of BiP associated with stress
2) Confidence 0.02 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2992128 Disease Relevance 0.25 Pain Relevance 0

General Comments

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