INT172039

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.02
Pain Relevance 1.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma cells 1
AFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 30 99.72 Very High Very High Very High
rheumatoid arthritis 470 99.68 Very High Very High Very High
Inflammation 35 69.76 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 35 99.72 Very High Very High Very High
Rheumatoid Arthritis 470 99.68 Very High Very High Very High
Disease 110 99.44 Very High Very High Very High
INFLAMMATION 25 69.76 Quite High
Systemic Lupus Erythematosus 45 5.00 Very Low Very Low Very Low
Autoimmune Disease 40 5.00 Very Low Very Low Very Low
Communicable Diseases 20 5.00 Very Low Very Low Very Low
Systemic Sclerosis 20 5.00 Very Low Very Low Very Low
Syndrome 10 5.00 Very Low Very Low Very Low
Mycobacterium Infection 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In RA pannus tissue, AFA are produced by local plasma cells and constitute a higher proportion of IgG than in serum [63].
Gene_expression (produced) of AFA in plasma cells associated with rheumatoid arthritis
1) Confidence 0.23 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.99 Pain Relevance 0.50
Vincent et al. [48] could detect AFA in 41% of RA sera with 99% specificity.
Gene_expression (detect) of AFA associated with rheumatoid arthritis
2) Confidence 0.23 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.15 Pain Relevance 0.08
AFA are present early in the disease, as is the case with APF and anti-CCP antibodies (see below), and raised AFA levels correlate with the severity of the disease.
Gene_expression (present) of AFA associated with disease
3) Confidence 0.23 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.78 Pain Relevance 0.21
AFA are present early in the disease, as is the case with APF and anti-CCP antibodies (see below), and raised AFA levels correlate with the severity of the disease.
Gene_expression (levels) of AFA associated with disease
4) Confidence 0.20 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.78 Pain Relevance 0.20
Using in vitro deiminated recombinant filaggrin, Nogueira et al. [53] could detect AFA in about 52% of RA sera.
Gene_expression (detect) of AFA associated with rheumatoid arthritis
5) Confidence 0.18 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.31 Pain Relevance 0.12

General Comments

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