INT172041

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.55
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (FLG) cytoplasmic membrane-bounded vesicle (FLG)
Anatomy Link Frequency
epidermis 2
filament 1
synovium 1
FLG (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 396 97.84 Very High Very High Very High
Inflammation 44 81.52 Quite High
Arthritis 29 79.60 Quite High
cytokine 15 79.20 Quite High
chemokine 7 78.32 Quite High
Inflammatory response 3 23.08 Low Low
Inflammatory stimuli 1 20.08 Low Low
psoriasis 22 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 397 97.84 Very High Very High Very High
Dermatitis 31 96.78 Very High Very High Very High
INFLAMMATION 39 81.52 Quite High
Arthritis 26 79.60 Quite High
Disease 112 74.72 Quite High
Targeted Disruption 4 72.92 Quite High
Rheumatic Diseases 9 53.72 Quite High
Shock 3 46.80 Quite Low
Stress 17 45.88 Quite Low
Contact Dermatitis 9 40.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Antiperinuclear factor/antikeratine antibodies/antifilaggrin/anti-CCP
Gene_expression (/) of filaggrin
1) Confidence 0.65 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 1.01 Pain Relevance 0.47
Filaggrin is not the natural autoantigen for ACPA because it is only expressed in epidermis.
Gene_expression (expressed) of Filaggrin in epidermis
2) Confidence 0.31 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779401 Disease Relevance 0.28 Pain Relevance 0.10
Filaggrin (filament aggregating protein) is involved in the organization of cytoskeletal structures in epithelial cells and is synthesized as a large, heavily phosphorylated precursor protein, profilaggrin.
Gene_expression (synthesized) of Filaggrin in filament
3) Confidence 0.22 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.23 Pain Relevance 0.11
Since filaggrin is not present in the joint, it is reasonable to assume that other citrulline-containing proteins are present in the RA synovium.
Neg (not) Gene_expression (present) of filaggrin in synovium associated with rheumatoid arthritis
4) Confidence 0.17 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128920 Disease Relevance 0.92 Pain Relevance 0.46
Filaggrin deficiency in the epidermis of AD patients is reasonably implicated in different, not yet clearly defined, aspects of CE malfunction in these subjects, including poor CE hydration and decreased generation of filaggrin acidic metabolites such as transurocanic acid, with consequent uncontrolled activation of serine proteases [70].
Gene_expression (generation) of filaggrin in epidermis associated with dermatitis
5) Confidence 0.15 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2929514 Disease Relevance 0.60 Pain Relevance 0.21
Palosuo et al. developed ELISA methods for detection of the antifilaggrin autoantibodies using purified human filaggrin and proposed a sensitivity of 71% for a specificity of 95% (16).
Gene_expression (using) of filaggrin
6) Confidence 0.14 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2782206 Disease Relevance 0.50 Pain Relevance 0.22

General Comments

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