INT172081

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.13
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
TNF (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Sicca syndrome 10 80.48 Quite High
rheumatoid arthritis 70 80.20 Quite High
Infliximab 91 79.08 Quite High
spinal inflammation 109 69.56 Quite High
Etanercept 42 67.24 Quite High
cytokine 6 37.04 Quite Low
antagonist 4 10.52 Low Low
Inflammation 27 7.04 Low Low
Arthritis 26 5.00 Very Low Very Low Very Low
cINOD 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 13 90.64 High High
Infection 23 86.88 High High
Latent Tuberculosis 3 85.92 High High
Granuloma 1 84.80 Quite High
Syndrome 14 80.48 Quite High
Rheumatoid Arthritis 73 80.20 Quite High
Low Back Pain 124 69.56 Quite High
Osteoarticular Tuberculosis 1 54.44 Quite High
Autoimmune Disease 7 46.96 Quite Low
Systemic Lupus Erythematosus 13 44.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, TNF seems to affect several aspects of the immune response to mycobacteria, including IFN-?
TNF Spec (seems) Regulation (affect) of IFN
1) Confidence 0.03 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 0.91 Pain Relevance 0.22
Whereas this finding suggested that TNF displays counteracting effects on IFN response activity, others have reported that TNF initiates an IRF1-dependent autocrine loop leading to sustained expression of STAT1-dependent type I IFN response genes [32].
TNF Regulation (effects) of IFN
2) Confidence 0.02 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875639 Disease Relevance 0.21 Pain Relevance 0.28

General Comments

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