INT172084

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Context Info
Confidence 0.50
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 15.31
Pain Relevance 6.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
macrophages 2
blood 2
synovial fluid 2
endothelial cells 2
HeLa 2
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 484 99.96 Very High Very High Very High
Adalimumab 120 99.68 Very High Very High Very High
corticosteroid 33 99.50 Very High Very High Very High
Etanercept 94 99.20 Very High Very High Very High
rheumatoid arthritis 301 99.12 Very High Very High Very High
cytokine 236 99.08 Very High Very High Very High
antagonist 39 98.08 Very High Very High Very High
Neuritis 2 95.08 Very High Very High Very High
chemokine 42 94.28 High High
tolerance 12 93.36 High High
Disease Link Frequency Relevance Heat
Latent Tuberculosis 10 100.00 Very High Very High Very High
Infection 86 99.98 Very High Very High Very High
INFLAMMATION 550 99.96 Very High Very High Very High
Tumor Necrosis Factor Receptor-associated Periodic Syndrome 65 99.78 Very High Very High Very High
Lung Injury 3 99.74 Very High Very High Very High
Mucositis 56 99.40 Very High Very High Very High
Diabetes Mellitus 43 99.24 Very High Very High Very High
Rheumatoid Arthritis 308 99.12 Very High Very High Very High
Skin Infection 18 98.92 Very High Very High Very High
Obesity 72 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upon binding to TNF-?
Positive_regulation (Upon) of TNF Binding (binding) of
1) Confidence 0.50 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2504074 Disease Relevance 0.89 Pain Relevance 0.50
expression in the synovium, as shown by immunohistochemistry.7 Of interest, the findings are also in accordance with a recent study suggesting that clinical response at 52 weeks is associated with significantly higher circulating TNF?
Positive_regulation (response) of TNF Binding (associated) of in synovium
2) Confidence 0.49 Published 2008 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2564801 Disease Relevance 0.32 Pain Relevance 0.25
The cytokine profiles for mutated peptide vaccinated mice indicated a peptide-specific response with elevated Th1 (TNF-?
Positive_regulation (response) of TNF Binding (indicated) of associated with cytokine
3) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.24 Pain Relevance 0.29
and NO by LPS-activated macrophages, and TNF-?
Positive_regulation (activated) of TNF Binding (macrophages) of in macrophages
4) Confidence 0.49 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2562783 Disease Relevance 0.42 Pain Relevance 0.25
, affecting the stabilization of the transcripts, full activation of membrane-bound TNF-?
Positive_regulation (activation) of TNF Binding (bound) of
5) Confidence 0.49 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1906815 Disease Relevance 0.45 Pain Relevance 0.12
After adjusting for age, sex, fitness level, and either TNF-?
Positive_regulation (adjusting) of TNF Binding (age) of
6) Confidence 0.49 Published 2008 Journal Diabetes Section Body Doc Link PMC2570404 Disease Relevance 0.99 Pain Relevance 0.11
Increased blood concentrations of TNF-?
Positive_regulation (Increased) of TNF Binding (concentrations) of in blood
7) Confidence 0.49 Published 2005 Journal Immun Ageing Section Body Doc Link PMC1166571 Disease Relevance 1.87 Pain Relevance 0.26
The severity of lung injury seems to be related negatively with BALF IL-1, TNF-?
Positive_regulation (negatively) of TNF Binding (related) of in lung associated with lung injury
8) Confidence 0.49 Published 2002 Journal Respir Res Section Body Doc Link PMC150513 Disease Relevance 0.58 Pain Relevance 0.16
Some opportunistic infections seem to be selectively associated with individual treatments, presumably illuminating mechanisms important in specific immune defence; for example, the reactivation of latent tuberculosis after anti-TNF therapy, illuminating the key role played by TNF?
Positive_regulation (reactivation) of TNF Binding (therapy) of associated with opportunistic infections and latent tuberculosis
9) Confidence 0.49 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721358 Disease Relevance 0.63 Pain Relevance 0.07
IL-11 is present in synovial membrane, synovial fluid and sera of RA patients, and blockade of endogenous IL-11 increases endogenous TNF-?
Positive_regulation (increases) of TNF Binding (endogenous) of in synovial fluid associated with rheumatoid arthritis
10) Confidence 0.49 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.68 Pain Relevance 0.50
No increase in circulating levels of total TNF binding activity was reported, however, in 16 subjects who were not taking systemic anti-TNF therapy.
Neg (No) Positive_regulation (increase) of TNF Binding (binding) of
11) Confidence 0.32 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483436 Disease Relevance 0.48 Pain Relevance 0.41
At present, it is unclear whether there is an increased risk of such disorders associated with anti-TNF therapy.
Spec (whether) Positive_regulation (increased) of anti-TNF Binding (associated) of
12) Confidence 0.30 Published 2002 Journal Arthritis Res Section Body Doc Link PMC128942 Disease Relevance 1.16 Pain Relevance 0.60
mediators, TNF and NFkB, have been shown to increase along the length of the
Positive_regulation (increase) of TNF Binding (mediators) of
13) Confidence 0.27 Published 2008 Journal Journal of Oncology Section Body Doc Link PMC2648637 Disease Relevance 0.73 Pain Relevance 0.31
In basal conditions binding to TRADD and RIP was minimal, however, following stimulation with TNF?
Positive_regulation (following) of TNF Binding (stimulation) of
14) Confidence 0.19 Published 2010 Journal Cellular Signalling Section Body Doc Link PMC2806525 Disease Relevance 0 Pain Relevance 0
In HeLa cells the human COX-2 promoter is fully inducible with PMA, but only to a low amount with TNF, whereas a synthetic NF-?
Positive_regulation (inducible) of TNF Binding (amount) of in HeLa
15) Confidence 0.18 Published 2002 Journal BMC Mol Biol Section Body Doc Link PMC140029 Disease Relevance 0 Pain Relevance 0.07
These differences result from the indication for TNF-?
Positive_regulation (result) of TNF Binding (indication) of
16) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174960 Disease Relevance 1.24 Pain Relevance 0.46
However, most infections occurred during active treatment with TNF-?
Positive_regulation (occurred) of TNF Binding (treatment) of associated with infection
17) Confidence 0.13 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174960 Disease Relevance 1.40 Pain Relevance 0.22
Independent of ATP, the p38-MAPK system seems to be essential for the action of TNF-?
Positive_regulation (essential) of TNF Binding (action) of
18) Confidence 0.13 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.89 Pain Relevance 0.62
A second theory was that TRAPS mutations increase the affinity of the receptor for TNF?
Positive_regulation (increase) of TNF Binding (affinity) of associated with tumor necrosis factor receptor-associated periodic syndrome
19) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206363 Disease Relevance 0.76 Pain Relevance 0.09
Corticosteroids also do not inhibit the increased concentrations of IL-8 and TNF-?
Positive_regulation (increased) of TNF Binding (concentrations) of associated with corticosteroid
20) Confidence 0.06 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2699952 Disease Relevance 1.24 Pain Relevance 0.66

General Comments

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