INT172097

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Context Info
Confidence 0.02
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.71
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HLA-E)
Anatomy Link Frequency
T-cell 10
HLA-E (Homo sapiens)
Trav6-3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 216 94.72 High High
tolerance 58 90.64 High High
rheumatoid arthritis 261 85.72 High High
cytokine 145 84.76 Quite High
Arthritis 81 79.60 Quite High
antagonist 4 49.04 Quite Low
Inflammatory response 1 46.16 Quite Low
Osteoarthritis 1 8.28 Low Low
psoriasis 14 5.00 Very Low Very Low Very Low
Kinase C 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 23 100.00 Very High Very High Very High
General Immunology 5 97.56 Very High Very High Very High
Disease 122 95.40 Very High Very High Very High
INFLAMMATION 210 94.72 High High
Cancer 382 91.56 High High
Sprains And Strains 6 87.36 High High
Rheumatoid Arthritis 261 85.72 High High
Lifespan 3 83.28 Quite High
Arthritis 85 80.64 Quite High
Autoimmune Disease 99 73.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During T-cell stimulation, the recognition of the peptide-MHC complex by a TCR induces clustering of the TCR in concert with other cell surface receptors.
MHC Binding (complex) of TCR in T-cell
1) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.15 Pain Relevance 0.04
During T-cell stimulation, the recognition of the peptide-MHC complex by a TCR induces clustering of the TCR in concert with other cell surface receptors.
MHC Binding (complex) of TCR in T-cell
2) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.15 Pain Relevance 0.04
During T-cell stimulation, the recognition of the peptide-MHC complex by a TCR induces clustering of the TCR in concert with other cell surface receptors.
MHC Binding (recognition) of TCR in T-cell
3) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.15 Pain Relevance 0.04
The new model is based on a transgene encoded T-cell receptor (TCR) that recognizes a self-component in the context of the mouse MHC class II molecule I-Ag7 (formerly known as I-ANOD).
MHC Binding (recognizes) of TCR in T-cell
4) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129986 Disease Relevance 0.97 Pain Relevance 0.39
The first signal is mediated by the interaction between the peptide/MHC complex on the surface of antigen presenting cells (APC) and the T-cell receptor (TCR) on the surface of T-cells.
MHC Binding (complex) of TCR in T-cell
5) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.74 Pain Relevance 0
The first signal is mediated by the interaction between the peptide/MHC complex on the surface of antigen presenting cells (APC) and the T-cell receptor (TCR) on the surface of T-cells.
MHC Binding (complex) of TCR in T-cell
6) Confidence 0.01 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.74 Pain Relevance 0
Signal 1 is delivered by the T-cell receptor (TCR) recognizing the antigenic peptide within the context of the major histocompatibility complex (MHC) molecule.
MHC Binding (recognizing) of TCR in T-cell
7) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.17 Pain Relevance 0.04
Signal 1 is delivered by the T-cell receptor (TCR) recognizing the antigenic peptide within the context of the major histocompatibility complex (MHC) molecule.
MHC Binding (recognizing) of TCR in T-cell
8) Confidence 0.00 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2582810 Disease Relevance 0.17 Pain Relevance 0.04
To circumvent these potential problems, T cells could be engineered to recognize a joint antigen with an appropriate MHC restriction via TCR gene transfer to obtain artificial autoreactive T cells.28,29 A recent clinical trial has raised the serious question of retrovirus-mediated gene therapy.
MHC Binding (recognize) of TCR gene in T cells
9) Confidence 0.00 Published 2006 Journal Mod Rheumatol Section Body Doc Link PMC2780633 Disease Relevance 0.20 Pain Relevance 0.03
In chimeras, the frequency of certain superantigen-reactive T-cell populations correlates with the deletion of ‘truly alloreactive’, donor-specific CD4 cells (as it can be assessed directly by employing TCR-transgenic T cells recognizing donor MHC [39]) and hence is a useful surrogate marker to measure whether deletion occurs (3,4).
MHC Binding (recognizing) of TCR in T cells associated with targeted disruption
10) Confidence 0.00 Published 2010 Journal American Journal of Transplantation Section Body Doc Link PMC2856406 Disease Relevance 0.26 Pain Relevance 0.08

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