INT172100

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.31
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TOP1) nuclear chromosome (TOP1) nucleolus (TOP1)
nucleus (TOP1) DNA binding (TOP1) cytoplasm (TOP1)
Anatomy Link Frequency
nucleus 1
TOP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 1 56.88 Quite High
Fibrositis 1 55.12 Quite High
Osteoarthritis 1 54.56 Quite High
rheumatoid arthritis 9 5.00 Very Low Very Low Very Low
Arthritis 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Sclerosis 99 97.60 Very High Very High Very High
Colon Cancer 43 91.36 High High
Apoptosis 60 75.76 Quite High
Death 7 65.60 Quite High
Pain 1 56.88 Quite High
Crystal Associated Disease 1 55.36 Quite High
Sleep Disorders 1 55.12 Quite High
Cancer 23 54.72 Quite High
Osteoarthritis 1 54.56 Quite High
Repression 3 40.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PKC interactions in the cytoplasm of NIH3T3 fibroblasts [27,30], and Par-4/TOP1 interactions in the nucleus of immortalized epithelial cells impede NF?
TOP1 Binding (interactions) of in nucleus
1) Confidence 0.14 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2883962 Disease Relevance 0.61 Pain Relevance 0
The authors also found that the association between solvents and SSc was present only among those subjects who tested positive for anti-Scl-70 antibody, suggesting that solvents may bind to topoisomerase I and trigger an autoimmune response in susceptible individuals.
topoisomerase I Binding (bind) of associated with systemic sclerosis
2) Confidence 0.06 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129987 Disease Relevance 0.70 Pain Relevance 0.11

General Comments

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