INT172104

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Context Info
Confidence 0.41
First Reported 2000
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 3.89
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (C4b) extracellular region (C4b)
C4b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 82.48 Quite High
Dysuria 3 59.32 Quite High
depression 3 57.48 Quite High
Inflammation 18 42.16 Quite Low
Arthritis 3 31.60 Quite Low
rheumatoid arthritis 35 5.00 Very Low Very Low Very Low
fibrosis 15 5.00 Very Low Very Low Very Low
tolerance 4 5.00 Very Low Very Low Very Low
Multiple sclerosis 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Systemic Lupus Erythematosus 105 99.24 Very High Very High Very High
Shock 2 97.98 Very High Very High Very High
Malaria 79 97.52 Very High Very High Very High
Targeted Disruption 30 95.04 Very High Very High Very High
Acute-phase Reaction 3 86.52 High High
Apoptosis 27 84.96 Quite High
Edema 6 83.80 Quite High
Cancer 2 82.40 Quite High
Necrosis 2 81.84 Quite High
Alzheimer's Dementia 3 80.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It acts via three mechanisms: preventing the formation of the C3 convertase by binding to C4b; accelerating the natural decay of the classical pathway C3 convertase; and as a cofactor for the serine proteinase factor I in the proteolytic inactivation of C4b, which prevents the formation of the C3 convertase.
C4b Binding (binding) of
1) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.47 Pain Relevance 0.07
The 8.5-kilobase-pair allele at the heat shock protein HSP70-2 locus has been shown to be associated with SLE in African Americans (independent of associations with the null allele at the C4 locus or HLA-DR3) [25].
C4 Binding (associations) of associated with shock and systemic lupus erythematosus
2) Confidence 0.36 Published 2000 Journal Arthritis Res Section Body Doc Link PMC129994 Disease Relevance 0.90 Pain Relevance 0
The mechanism by which the Sl2 and McCb alleles could confer protection from severe malaria is not known, since these polymorphisms are located near the C-terminus of the CR1 molecule in an area that is outside the binding sites for C3b, C4b, and PfEMP-1.
C4b Binding (binding) of associated with malaria
3) Confidence 0.36 Published 2005 Journal Malar J Section Body Doc Link PMC1308855 Disease Relevance 0.67 Pain Relevance 0
LHR-A binds C4b, whereas LHR-B and C bind both C4b and C3b.
C4b Binding (bind) of
4) Confidence 0.35 Published 2005 Journal Malar J Section Body Doc Link PMC1308855 Disease Relevance 0.75 Pain Relevance 0
As shown with human C4bp the mouse C4bp binds both mouse C4b in vivo and in vitro [25,27], and mouse C4 is unable to form a functional C3 convertase when bound to C4bp [27].
C4 Binding (bound) of
5) Confidence 0.31 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.52 Pain Relevance 0
chain is composed of eight complement control protein domains, and the N-terminal three complement control proteins bind C4b [14].
C4b Binding (bind) of
6) Confidence 0.27 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212569 Disease Relevance 0.58 Pain Relevance 0.06

General Comments

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