INT172141

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Context Info
Confidence 0.14
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.89
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
intracellular (IL10) cell-cell signaling (IL10) response to stress (IL10)
Anatomy Link Frequency
monocytes 8
IL10 (Homo sapiens)
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 65 97.96 Very High Very High Very High
fibrosis 1 94.76 High High
chemokine 4 84.96 Quite High
antagonist 22 82.96 Quite High
Arthritis 37 81.44 Quite High
anesthesia 51 77.76 Quite High
rheumatoid arthritis 88 73.28 Quite High
Inflammation 76 61.04 Quite High
Neurotransmitter 3 47.04 Quite Low
substance P 9 27.52 Quite Low
Disease Link Frequency Relevance Heat
Fibrosis 1 94.76 High High
Stress 15 89.64 High High
Autoimmune Disease 3 86.80 High High
Arthritis 36 81.44 Quite High
Experimental Arthritis 6 80.88 Quite High
Hypercalcemia 2 75.04 Quite High
Rheumatoid Arthritis 91 73.28 Quite High
INFLAMMATION 85 61.04 Quite High
Disease 20 5.84 Low Low
Systemic Inflammatory Response Syndrome 21 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-10 down-regulated HLA-DR expression on CD14HIGH monocytes, but not on CD14LOW cells (Figure 5).
IL-10 Negative_regulation (down) of Gene_expression (expression) of HLA-DR in monocytes
1) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.23
IL-10 down-regulated HLA-DR expression on CD14HIGH monocytes, but not on CD14LOW cells (Figure 5).
IL-10 Negative_regulation (regulated) of Gene_expression (expression) of HLA-DR in monocytes
2) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.23
IL-10 down-regulated HLA-DR expression on CD14HIGH monocytes, but not on CD14LOW cells (Figure 5).
IL-10 Negative_regulation (-) of Gene_expression (expression) of HLA-DR in monocytes
3) Confidence 0.14 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0.09 Pain Relevance 0.23
Accordingly, IL-10 reduces HLA-DR expression and antigen presentation in monocytes [87] and inhibits the production of proinflammatory cytokines, GM-CSF and Fc?
IL-10 Negative_regulation (reduces) of Gene_expression (expression) of HLA-DR in monocytes associated with cytokine
4) Confidence 0.03 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.62 Pain Relevance 0.54

General Comments

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