INT172148

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Context Info
Confidence 0.05
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.67
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2, TNF) extracellular region (IL2, TNF) signal transduction (TNF)
cell adhesion (IL2) plasma membrane (TNF) intracellular (TNF)
Anatomy Link Frequency
T cells 1
IL2 (Homo sapiens)
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 88 90.48 High High
metalloproteinase 7 89.40 High High
cytokine 53 76.32 Quite High
Inflammation 37 76.20 Quite High
antagonist 10 28.48 Quite Low
Arthritis 37 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Papillomavirus Infection 1 100.00 Very High Very High Very High
Rheumatoid Arthritis 91 90.48 High High
INFLAMMATION 37 76.20 Quite High
Skin Cancer 1 24.16 Low Low
Disease 22 21.04 Low Low
Arthritis 36 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 5.00 Very Low Very Low Very Low
Synovitis 7 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, fixed T cells stimulated in an antigen-independent manner (ie with IL-15, IL-2, or a combination of IL-6 and TNF-?)
IL-2 Binding (combination) of TNF in T cells
1) Confidence 0.05 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.57 Pain Relevance 0.37
Indeed, all but one of the modulators discussed in a recent review article [2] were identified by the method: Interleukin-2 – Interleukin-2 receptor (PDB 2ERJ:A,D; 1PY2:FRH), MDM2–p53 (1T4F:M,P; 1T4E:DIZ), HPV E2–E1 helicase (1TUE:A,B; 1R6N:434), ZipA–FtsZ (1F47:A,B; 1Y2F:WAI), and TNF- homotrimer (2TNF; 2AZ5:307).
Interleukin-2 Binding (receptor) of TNF associated with papillomavirus infection
2) Confidence 0.03 Published 2010 Journal PLoS Computational Biology Section Body Doc Link PMC2816688 Disease Relevance 0.10 Pain Relevance 0

General Comments

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