INT172149

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Context Info
Confidence 0.01
First Reported 2000
Last Reported 2000
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A, IL1B) extracellular region (IL17A, IL1B) cell-cell signaling (IL17A, IL1B)
cytosol (IL1B) signal transduction (IL1B) aging (IL1B)
Anatomy Link Frequency
macrophages 2
IL17A (Homo sapiens)
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 88 100.00 Very High Very High Very High
Osteoarthritis 1 100.00 Very High Very High Very High
cytokine 53 95.40 Very High Very High Very High
antagonist 10 52.04 Quite High
Inflammation 37 40.80 Quite Low
Arthritis 37 18.16 Low Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
corticosteroid 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 91 100.00 Very High Very High Very High
Osteoarthritis 1 100.00 Very High Very High Very High
INFLAMMATION 37 40.80 Quite Low
Experimental Arthritis 6 19.20 Low Low
Arthritis 36 5.00 Very Low Very Low Very Low
Disease 20 5.00 Very Low Very Low Very Low
Synovitis 7 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Adhesions 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The lymphokine IL-17, which is produced in approximately 90% of RA synovial explant cultures, but only in 16% of osteoarthritis cultures, strongly stimulates macrophages to produce IL-1 and TNF-?
IL-17 Positive_regulation (stimulates) of Gene_expression (produce) of IL-1 in macrophages associated with rheumatoid arthritis and osteoarthritis
1) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.50 Pain Relevance 0.43

General Comments

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