INT17217

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Context Info
Confidence 0.31
First Reported 1984
Last Reported 2002
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.56
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
neuronal 2
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 12 100.00 Very High Very High Very High
Opioid 4 99.64 Very High Very High Very High
narcan 21 99.60 Very High Very High Very High
Enkephalin 3 99.50 Very High Very High Very High
opiate 10 99.48 Very High Very High Very High
Endogenous opioid 5 99.16 Very High Very High Very High
Dismenorea 4 94.24 High High
Migraine 9 93.60 High High
antagonist 6 90.80 High High
Dynorphin 5 88.12 High High
Disease Link Frequency Relevance Heat
Stress 8 100.00 Very High Very High Very High
Reprotox - General 3 2 99.24 Very High Very High Very High
Diabetes Mellitus-type I 2 96.16 Very High Very High Very High
Diabetes Mellitus 3 95.92 Very High Very High Very High
Reprotox - General 1 9 94.24 High High
Headache 5 93.60 High High
Migraine Without Aura 4 88.96 High High
Body Weight 2 78.08 Quite High
Depression 1 70.00 Quite High
Dizziness 1 68.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of endogenous opioid peptides (EOPs) on LH secretion was examined to investigate the neuronal mechanisms responsible for the inhibition of GnRH and the resultant infertility in nonreproductive female Damaraland mole-rats, Cryptomys damarensis.
Spec (investigate) Regulation (responsible) of Negative_regulation (inhibition) of GnRH in neuronal associated with reprotox - general 3 and endogenous opioid
1) Confidence 0.31 Published 2002 Journal Horm Behav Section Abstract Doc Link 11855897 Disease Relevance 0.10 Pain Relevance 0.33
Naloxone (500 micrograms), however, induced a twofold increase in LH levels within 15 min suggesting that an enhanced opiate rather than dopaminergic activity may be responsible for the suppression of GnRH and hence gonadotrophin secretion during suckling.
Regulation (responsible) of Negative_regulation (suppression) of GnRH associated with narcan and opiate
2) Confidence 0.25 Published 1984 Journal J. Endocrinol. Section Abstract Doc Link 6420492 Disease Relevance 0 Pain Relevance 0.41
LH responsiveness to LHRH was similar in the mid and late luteal phases and did not change between groups.
Neg (not) Regulation (change) of Negative_regulation (responsiveness) of LHRH
3) Confidence 0.18 Published 1988 Journal J Reprod Med Section Abstract Doc Link 3050071 Disease Relevance 1.15 Pain Relevance 1.39
Second, the hypothesis that increased central (hypothalamic) opiate inhibition may have been responsible for the suppression of gonadotropin-releasing hormone (GnRH) was tested by observing the effect of a four-hour naloxone infusion (1.4 mg/hour) on serum gonadotropin levels.
Regulation (responsible) of Negative_regulation (suppression) of GnRH associated with narcan and opiate
4) Confidence 0.08 Published 1987 Journal Am. J. Med. Section Abstract Doc Link 3332566 Disease Relevance 0.83 Pain Relevance 0.22
The possible role of alcohol-induced reductions in serum luteinizing hormone and testosterone levels in mediating the effects of alcohol on TIF volume was also examined.
Spec (possible) Regulation (role) of Negative_regulation (reductions) of serum luteinizing hormone associated with alcohol
5) Confidence 0.06 Published 1991 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 1890609 Disease Relevance 0 Pain Relevance 0.38
Opioids act centrally to modulate stress-induced decrease in luteinizing hormone in the rat.
Regulation (modulate) of Negative_regulation (decrease) of luteinizing hormone associated with stress and opioid
6) Confidence 0.02 Published 1986 Journal Endocrinology Section Title Doc Link 2877862 Disease Relevance 0.48 Pain Relevance 1.05

General Comments

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