INT172170

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Context Info
Confidence 0.04
First Reported 2000
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.59
Pain Relevance 0.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synovial cell 1
HV1S (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 96 96.40 Very High Very High Very High
Inflammation 88 96.00 Very High Very High Very High
Arthritis 67 85.92 High High
antagonist 14 79.32 Quite High
rheumatoid arthritis 175 68.08 Quite High
chemokine 16 43.20 Quite Low
metalloproteinase 7 5.00 Very Low Very Low Very Low
corticosteroid 6 5.00 Very Low Very Low Very Low
methotrexate 5 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 2 100.00 Very High Very High Very High
Aids-related Complex 1 99.88 Very High Very High Very High
INFLAMMATION 90 96.00 Very High Very High Very High
Apoptosis 46 95.12 Very High Very High Very High
Mouth Cancer 5 94.24 High High
Experimental Arthritis 19 85.92 High High
Skin Cancer 15 83.92 Quite High
Arthritis 59 72.16 Quite High
Rheumatoid Arthritis 178 68.08 Quite High
Disease 42 63.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An interesting approach of gene therapy is to achieve 'molecular synovectomy', either by expression of herpes simplex virus-thymidine kinase, with subsequent administration of ganciclovir [199,200], or by overexpression of Fas ligand, resulting in synovial cell apoptosis [201,202].
Gene_expression (expression) of herpes simplex virus-thymidine kinase in synovial cell associated with herpes simplex virus and apoptosis
1) Confidence 0.04 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.98 Pain Relevance 0.51
and to 'molecular synovectomy' (either by expression of herpes simplex virus-thymidine kinase with subsequent administration of ganciclovir or by overexpression of Fas-ligand/inhibitors of nuclear translocation of NF-?
Gene_expression (expression) of herpes simplex virus-thymidine kinase associated with herpes simplex virus
2) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.99 Pain Relevance 0.42
Arc, has produced reefs of special biogeographical interest, three kinds of Formosan soft corals, including Cladiella australis (Alcyoniidae), Clavularia viridis (Clavulariidae) and Klyxum simplex (Alcyoniidae), were collected to be evaluated for biomedical research.
Gene_expression (produced) of Klyxum simplex associated with aids-related complex
3) Confidence 0.01 Published 2008 Journal Mar Drugs Section Body Doc Link PMC2630851 Disease Relevance 0.62 Pain Relevance 0

General Comments

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