INT172171

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 47
Total Number 48
Disease Relevance 46.23
Pain Relevance 13.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (IL15) aging (IL15) Golgi apparatus (IL15)
cell-cell signaling (IL15) cytoplasm (IL15) extracellular space (IL15)
Anatomy Link Frequency
T cells 7
smooth muscle 4
synovial fluid 2
enterocyte 2
adipose tissue 2
IL15 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1590 100.00 Very High Very High Very High
cytokine 1292 100.00 Very High Very High Very High
Inflammation 1216 100.00 Very High Very High Very High
antagonist 182 100.00 Very High Very High Very High
Inflammatory marker 3 99.78 Very High Very High Very High
chemokine 358 99.60 Very High Very High Very High
Arthritis 496 96.00 Very High Very High Very High
tolerance 31 92.32 High High
Prostatitis 8 91.36 High High
anakinra 49 86.40 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1607 100.00 Very High Very High Very High
INFLAMMATION 1292 100.00 Very High Very High Very High
Obesity 163 100.00 Very High Very High Very High
Overweight 158 100.00 Very High Very High Very High
Adhesions 81 100.00 Very High Very High Very High
Asthma 630 99.98 Very High Very High Very High
Stress 40 99.90 Very High Very High Very High
Appetite Loss 89 99.88 Very High Very High Very High
Psoriasis 541 99.82 Very High Very High Very High
Cancer 394 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Gene_expression (expression) of IL-15 in T cells associated with inflammation, infarction and cytokine
1) Confidence 0.37 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.49
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Gene_expression (expression) of interleukin 15 in T cells associated with inflammation, infarction and cytokine
2) Confidence 0.37 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.11 Pain Relevance 0.49
We know now that the IL2R is a complex comprised by three parts: the alpha chain (CD25) which is required for high affinity binding, the beta chain (CD122) which participates in IL2 and IL15 signal transduction, and the common gamma chain (CD132) which participates in downstream signal transduction of IL2 and other cytokines.11–14
Gene_expression (transduction) of IL15 in IL2R associated with cytokine
3) Confidence 0.34 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 0.42 Pain Relevance 0.05
Other inflammatory markers that were expressed at higher level in adipose tissue from overweight subjects included leptin, complement factor D (CFD), interleukin receptor 6 (IL6R), interleukin receptor 10 alpha (IL10RA), interleukin 1 receptor antagonist (IL1RN) and a number of interleukins (IL15, IL17D, IL18) (data not shown).
Gene_expression (expressed) of IL15 in adipose tissue associated with antagonist, inflammatory marker, obesity and overweight
4) Confidence 0.34 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.83 Pain Relevance 0.13
Other inflammatory markers that were expressed at higher level in adipose tissue from overweight subjects included leptin, complement factor D (CFD), interleukin receptor 6 (IL6R), interleukin receptor 10 alpha (IL10RA), interleukin 1 receptor antagonist (IL1RN) and a number of interleukins (IL15, IL17D, IL18) (data not shown).
Gene_expression (complement) of IL15 in adipose tissue associated with antagonist, inflammatory marker, obesity and overweight
5) Confidence 0.34 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.72 Pain Relevance 0.13
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Gene_expression (produced) of IL-15 in T cells associated with inflammation, infarction and cytokine
6) Confidence 0.29 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.06 Pain Relevance 0.43
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Gene_expression (produced) of interleukin 15 in T cells associated with inflammation, infarction and cytokine
7) Confidence 0.29 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.12 Pain Relevance 0.46
IL-15 is detectable in the serum of patients with ulcerative colitis and psoriatic lesions express significant levels of IL-15.
Gene_expression (express) of IL-15 associated with psoriasis and inflammatory bowel disease
8) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.24 Pain Relevance 0.29
IL-15 is detectable in the serum of patients with ulcerative colitis and psoriatic lesions express significant levels of IL-15.
Gene_expression (detectable) of IL-15 associated with psoriasis and inflammatory bowel disease
9) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.14 Pain Relevance 0.28
The low expressed genes included SMAD1, IL-15, CXCL5.
Gene_expression (expressed) of IL-15
10) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.94 Pain Relevance 0.05
High levels of IL-7 and IL-15 mRNA and protein expression have been demonstrated in synovial tissue cells from RA patients [41].
Gene_expression (expression) of IL-15 associated with rheumatoid arthritis
11) Confidence 0.26 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.60 Pain Relevance 0.40
We also observed that IL-15 and IL-18 expressions were correlated with the local uNK (CD56+) recruitment and subendometrial angiogenesis as reflected by the vascular flow index quantified by 3-D ultrasound with angiography [6].
Gene_expression (expressions) of IL-15
12) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.43 Pain Relevance 0.15
In previous studies, we reported that IL-15 and IL-18 expressions were significantly different in patients who failed to implant when compared with fertile control individuals [5].
Gene_expression (expressions) of IL-15
13) Confidence 0.23 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.28 Pain Relevance 0.16
Similar findings were reported by Ziolkowska et al. [20], demonstrating elevated levels of IL-15 in synovial fluid from RA patients and a strong correlation between IL-15 concentrations and IL-17 levels [20].
Gene_expression (concentrations) of IL-15 in synovial fluid associated with rheumatoid arthritis
14) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.27 Pain Relevance 0.42
Similar findings were reported by Ziolkowska et al. [20], demonstrating elevated levels of IL-15 in synovial fluid from RA patients and a strong correlation between IL-15 concentrations and IL-17 levels [20].
Gene_expression (concentrations) of IL-15 in synovial fluid associated with rheumatoid arthritis
15) Confidence 0.22 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 1.30 Pain Relevance 0.43
Interestingly, IL-15 which is highly expressed in neural tissues and skeletal muscles [27] is released in large quantities following physical stress [28,29].
Gene_expression (expressed) of IL-15 in skeletal muscles associated with stress
16) Confidence 0.21 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.15 Pain Relevance 0.05
IL-7 is a well-known cytokine of the IL-2/IL-15 family and has been shown to be expressed by stromal cells (e.g., in bone marrow and thymus), epithelial cells, endothelial cells, fibroblasts, smooth muscle cells, and keratinocytes.
Gene_expression (expressed) of IL-15 in smooth muscle cells associated with cytokine
17) Confidence 0.20 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768824 Disease Relevance 0.55 Pain Relevance 0.39
Some pro-angiogenic factors (IL18, IL15, MMP10, MMP28) as well as cell adhesion molecules (CEACAM 1, CEACAM 5, CEACAM 6) were also overexpressed.
Gene_expression (overexpressed) of IL15 associated with adhesions
18) Confidence 0.19 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2927995 Disease Relevance 0.37 Pain Relevance 0
Lymphodepletion could act by eliminating competition for homeostatic cytokines, in particular IL15, for which high levels can be detected only after treatment.
Gene_expression (detected) of IL15 associated with cytokine
19) Confidence 0.17 Published 2010 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2952949 Disease Relevance 0.37 Pain Relevance 0.08
The infiltrate consists predominantly of chronically activated CD4(+) T lymphocytes, which are permanently recruited to the prostate tissue via elevated expression of interleukin 15 (IL-15) and interferon gamma (IFN-gamma), pro-inflammatory cytokines produced by smooth muscle and T cells, respectively.[37]

Prostatic infarction

Gene_expression (expression) of interleukin 15 in smooth muscle associated with inflammation, infarction and cytokine
20) Confidence 0.13 Published 2007 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2721562 Disease Relevance 2.11 Pain Relevance 0.49

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