INT172173

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Context Info
Confidence 0.96
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 9.95
Pain Relevance 3.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNF) extracellular space (TNF) extracellular region (TNF)
plasma membrane (TNF) intracellular (TNF) extracellular matrix organization (TNF)
Anatomy Link Frequency
somatic cell 1
Cleavage 1
TNF (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 6 100.00 Very High Very High Very High
Inflammation 307 99.46 Very High Very High Very High
metalloproteinase 43 98.52 Very High Very High Very High
cytokine 275 97.74 Very High Very High Very High
Bioavailability 157 95.64 Very High Very High Very High
rheumatoid arthritis 359 94.88 High High
Inflammatory response 13 94.36 High High
Infliximab 102 93.04 High High
fibrosis 40 91.68 High High
Etanercept 87 88.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 320 99.46 Very High Very High Very High
Infection 610 99.16 Very High Very High Very High
Disease 316 98.82 Very High Very High Very High
Hypercalcemia 5 98.16 Very High Very High Very High
Necrosis 62 95.08 Very High Very High Very High
Rheumatoid Arthritis 363 94.88 High High
Cancer 62 94.72 High High
Purpura 1 94.40 High High
Apoptosis 139 92.72 High High
Acute-phase Reaction 2 92.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As an additional control for the suitability of the samples and the stability of the overall approach, TNF-?
Protein_catabolism (stability) of TNF
1) Confidence 0.96 Published 2005 Journal PLoS Medicine Section Body Doc Link PMC1188246 Disease Relevance 0.48 Pain Relevance 0.05
Unlike IL-4, IL-10 can also enhance degradation of the mRNA for IL-1 and TNF-?
Protein_catabolism (degradation) of TNF
2) Confidence 0.86 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.86 Pain Relevance 0.31
that is cleaved into sTNF in vivo.
Protein_catabolism (cleaved) of sTNF
3) Confidence 0.77 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.22 Pain Relevance 0
Using the model, we investigate how different percentages of total TNF cleaved (i.e., sTNF) affect infection progression.
Protein_catabolism (cleaved) of TNF associated with infection
4) Confidence 0.65 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.69 Pain Relevance 0.11
cleaved TNF.
Protein_catabolism (cleaved) of TNF
5) Confidence 0.65 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.20 Pain Relevance 0
(percentage of total TNF cleaved and released as sTNF).
Protein_catabolism (cleaved) of TNF
6) Confidence 0.65 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.19 Pain Relevance 0.15
This inflammatory pathway is initiated when TNF is cleaved from the cell surface by a specific metalloproteinase and binds to its two receptors, TNFR-55 and TNFR-75, found in both soluble forms and on somatic cell surfaces.
Protein_catabolism (cleaved) of TNF in somatic cell associated with inflammation and metalloproteinase
7) Confidence 0.65 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721344 Disease Relevance 1.00 Pain Relevance 0.81
Thalidomide inhibits TNF through enhanced degradation of TNF mRNA [118,119], however is can also alter the expression of COX-2, IL-1?
Protein_catabolism (degradation) of TNF mRNA
8) Confidence 0.58 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2577641 Disease Relevance 0.26 Pain Relevance 0.16
is approximately 95% (i.e., only 5% TNF is transmembrane) so that the majority of tmTNF is cleaved and released in its bioactive soluble form.
Protein_catabolism (cleaved) of tmTNF
9) Confidence 0.57 Published 2007 Journal PLoS Computational Biology Section Body Doc Link PMC2041971 Disease Relevance 0.19 Pain Relevance 0
The absence of disease flares in the washout group excludes the possibility that deterioration after withdrawal of anti-TNF-?
Protein_catabolism (deterioration) of TNF associated with disease and withdrawal
10) Confidence 0.50 Published 2006 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1936358 Disease Relevance 0.30 Pain Relevance 0.34
Unlike IL-4, IL-10 can also enhance degradation of the mRNA for IL-1 and TNF-?
Protein_catabolism (degradation) of TNF
11) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 0.82 Pain Relevance 0.37
mRNA/protein in situ [40], the degree of TNF-?
Protein_catabolism (degree) of TNF
12) Confidence 0.45 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246244 Disease Relevance 1.27 Pain Relevance 0.46
Classification as drug-related eruption was based on a time relation with administration of the TNF-?
Protein_catabolism (administration) of TNF
13) Confidence 0.24 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174960 Disease Relevance 0.54 Pain Relevance 0.13
Cleavage of the TNF-?
Protein_catabolism (Cleavage) of TNF in Cleavage
14) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.12 Pain Relevance 0.58
The pro-TNF is cleaved by a metalloprotease releasing the 17 kDa extracellular portion of the molecule [222,226].
Protein_catabolism (cleaved) of pro-TNF
15) Confidence 0.14 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.61 Pain Relevance 0.03
has been suggested as a cytokine mediating the manifestation of psoriasiform lesions in patients treated with TNF-inhibitors as a consequence of crosstalk of TNF-?
Protein_catabolism (crosstalk) of TNF associated with cytokine
16) Confidence 0.11 Published 2008 Journal Arch Dermatol Res Section Body Doc Link PMC2254657 Disease Relevance 1.19 Pain Relevance 0.28

General Comments

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