INT172177

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Context Info
Confidence 0.37
First Reported 2000
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 6.34
Pain Relevance 2.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (INCENP) chromosome segregation (INCENP) chromosome (INCENP)
cytoskeleton (INCENP) nucleus (INCENP) protein complex (INCENP)
Anatomy Link Frequency
cartilage 2
macrophages 1
diaphragm 1
extracellular matrix 1
fibroblasts 1
INCENP (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 290 99.28 Very High Very High Very High
Osteoarthritis 79 97.60 Very High Very High Very High
antagonist 51 97.48 Very High Very High Very High
Dopamine 78 95.00 High High
Inflammation 240 94.48 High High
anesthesia 22 93.92 High High
rheumatoid arthritis 308 93.60 High High
chemokine 25 86.72 High High
Substantia nigra 6 82.72 Quite High
Potency 6 82.16 Quite High
Disease Link Frequency Relevance Heat
Sepsis 13 99.64 Very High Very High Very High
Knee Osteoarthritis 67 97.60 Very High Very High Very High
Cytomegalovirus Infection 274 97.44 Very High Very High Very High
Shock 4 96.92 Very High Very High Very High
INFLAMMATION 270 94.48 High High
Rheumatoid Arthritis 317 93.60 High High
Injury 98 92.16 High High
Cancer 76 85.24 High High
Vesicular Stomatitis 2 84.04 Quite High
Respiratory Syncytial Virus 2 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The number of times the film could be folded at the same place without breaking gave the value of folding endurance.[10]

In-vitro disintegration study

Protein_catabolism (disintegration) of In-vitro
1) Confidence 0.37 Published 2010 Journal Journal of Pharmacy and Bioallied Sciences Section Body Doc Link PMC2996061 Disease Relevance 0 Pain Relevance 0
In vitro autoradiography
Protein_catabolism (autoradiography) of In vitro
2) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2920085 Disease Relevance 0.07 Pain Relevance 0.26
More recent studies [65] have shown that purified human synovial fibroblasts cocultured with myelomonocytic cell lines induce cartilage degradation in vitro.
Protein_catabolism (degradation) of in vitro in cartilage
3) Confidence 0.02 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.39 Pain Relevance 0.42
Also, in vitro model systems show significant cartilage degradation by cocultures of mouse fibroblasts and macrophages, a response markedly exceeding that observed with each culture alone [64].
Protein_catabolism (degradation) of in vitro in macrophages
4) Confidence 0.02 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.38 Pain Relevance 0.43
In vitro proteolysis
Protein_catabolism (proteolysis) of In vitro
5) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2592744 Disease Relevance 0.50 Pain Relevance 0
It is interesting to note that, in the study of Shanely and colleagues [11], the results were obtained from the analysis of separate studies of in vitro proteolysis and in vivo protein synthesis.
Protein_catabolism (proteolysis) of in vitro
6) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2592744 Disease Relevance 0.52 Pain Relevance 0
After sacrifice and incubation with 14C-phenylalanine, in vitro proteolysis and protein synthesis were measured on the costal region of the diaphragm.
Protein_catabolism (proteolysis) of in vitro in diaphragm
7) Confidence 0.02 Published 2008 Journal Crit Care Section Abstract Doc Link PMC2592744 Disease Relevance 0.50 Pain Relevance 0.09
On the other hand, in vivo protein synthesis should be more relevant than in vitro proteolysis as used in our study.
Protein_catabolism (proteolysis) of in vitro
8) Confidence 0.02 Published 2008 Journal Crit Care Section Body Doc Link PMC2592744 Disease Relevance 0.42 Pain Relevance 0
In vivo, damage signals and intact extracellular matrix (ECM) degradation activate TLR4 [52].
Protein_catabolism (degradation) of In vivo in extracellular matrix
9) Confidence 0.01 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.92 Pain Relevance 0.14
IFNs are N-glycosylated, but glycosylation does not correlate with activity of the molecule, but rather with in vivo stability, and recombinant IFNs are shown to have activity comparable with that of the naturally produced molecules [185,188].
Protein_catabolism (stability) of in vivo
10) Confidence 0.01 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0 Pain Relevance 0.07
In vitro and in vivo stability
Protein_catabolism (stability) of in vivo
11) Confidence 0.01 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2877043 Disease Relevance 0 Pain Relevance 0
A study by Moore et al. [14] examined bovine pericardial tissue treated by photooxidation and found that the resultant tissue was resistant to chemical and enzymatic digestion, maintained some of the physical properties of natural pericardial tissue, and was more resistant to in vivo degradation.
Protein_catabolism (degradation) of in vivo
12) Confidence 0.01 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1459156 Disease Relevance 0.28 Pain Relevance 0.03
Mahato et al reported that a standard tail vein injection of naked DNA into mice resulted in almost no gene expression in major organs due to its rapid in vivo degradation by nucleases and clearance by the monocular phagocyte system [89].
Protein_catabolism (degradation) of in vivo in phagocyte
13) Confidence 0.01 Published 2010 Journal Int Arch Med Section Body Doc Link PMC3016243 Disease Relevance 0.26 Pain Relevance 0
Indeed, the esters may form pyrazine-type degradation products in vitro and in vivo before or after hydrolysis.
Protein_catabolism (degradation) of in vitro
14) Confidence 0.01 Published 2007 Journal Perspectives in Medicinal Chemistry Section Body Doc Link PMC2754918 Disease Relevance 0.08 Pain Relevance 0
Both cytokines have been shown to potently induce degradation of cartilage in vitro [31].
Protein_catabolism (degradation) of in vitro in cartilage associated with cytokine
15) Confidence 0.01 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.97 Pain Relevance 0.68
One unresolved concern is the stability of these regioisomers in vivo due to the relatively fast rate of acyl migration towards a 9:1 (sn1: sn2) equilibrium ratio of the isomers (Wang et al., 1997; Croset et al., 2000).
Protein_catabolism (stability) of in vivo
16) Confidence 0.01 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0 Pain Relevance 0.03
Also, in vitro model systems show significant cartilage degradation by cocultures of mouse fibroblasts and macrophages, a response markedly exceeding that observed with each culture alone [64].
Protein_catabolism (degradation) of in vitro in fibroblasts
17) Confidence 0.01 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.38 Pain Relevance 0.43
In vitro, pGSN can be cleaved by MMPs into fragments of 42 to 46 kDa (at Asn416-Val417, Ser51-Met52, and Ala435-Gln436) [33,35].
Protein_catabolism (cleaved) of In vitro
18) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592804 Disease Relevance 0.67 Pain Relevance 0.33

General Comments

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