INT172179

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Context Info
Confidence 0.55
First Reported 2000
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 7
Total Number 13
Disease Relevance 4.29
Pain Relevance 2.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL11) extracellular region (IL11) cell-cell signaling (IL11)
cytoplasm (IL11)
Anatomy Link Frequency
macrophages 4
fibroblasts 2
stem cells 1
neutrophils 1
IL11 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 166 100.00 Very High Very High Very High
Osteoarthritis 77 100.00 Very High Very High Very High
rheumatoid arthritis 182 94.72 High High
chemokine 9 93.44 High High
Inflammation 99 91.60 High High
Arthritis 75 88.40 High High
metalloproteinase 45 54.32 Quite High
fibrosis 2 43.56 Quite Low
nociceptor 2 16.16 Low Low
Pain 29 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Knee Osteoarthritis 67 100.00 Very High Very High Very High
Rheumatoid Arthritis 188 94.72 High High
Down Syndrome 7 92.56 High High
INFLAMMATION 107 91.60 High High
Keloid Scars 3 89.32 High High
Arthritis 74 88.40 High High
Necrosis 11 76.24 Quite High
Cancer 11 75.88 Quite High
Peripheral Arterial Disease 7 72.44 Quite High
Ulcers 87 67.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Subsequently, we have shown that both IL-11 and GP130 mRNA expression are elevated in the late secretory phase of the menstrual cycle whereas IL-11R?
Positive_regulation (elevated) of Gene_expression (expression) of IL-11
1) Confidence 0.55 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
Moreover, using a specific inhibitor, INCA-6, which is known to block the interaction between calcineurin and NFAT (Roehrl et al., 2004), we have shown that inhibiting NFAT signalling can block PROK1-PROKR1 mediated expression of IL-11.
Positive_regulation (mediated) of Gene_expression (expression) of IL-11
2) Confidence 0.55 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
To investigate the signalling pathways mediating the role of PROK1 on IL-11 expression, PROKR1 Ishikawa cells were stimulated with vehicle or 40 nM PROK1 for 6 h in the presence or absence of the chemical inhibitors of Gq/11 (YM254890), a calcium chelator (EGTA), ERK (PD98059), NFAT (INCA-6) or calcineurin (CSA; cyclosporine A).
Spec (investigate) Positive_regulation (mediating) of Gene_expression (expression) of IL-11
3) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0
RCAN1-4 overexpression inhibits PROK1-induced expression of IL-11
Positive_regulation (induced) of Gene_expression (expression) of IL-11
4) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.09 Pain Relevance 0
PROK1 induced expression of IL-11 mRNA at 24 h was significantly reduced by co-treatment of tissue explants with a Gq/11 inhibitor (P < 0.05), a calcium chelator (P < 0.01) or an ERK inhibitor (P < 0.01) (Fig. 5B).
Positive_regulation (induced) of Gene_expression (expression) of IL-11
5) Confidence 0.40 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
No increase in IL-11 expression was observed in wild-type Ishikawa cells.
Neg (No) Positive_regulation (increase) of Gene_expression (expression) of IL-11
6) Confidence 0.37 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
Furthermore we have shown that overexpression of regulator of calcineurin 1 isoform 4 (RCAN1-4)—a negative regulator of calcineurin signalling—leads to a reduction in PROK1 induced IL-11, indicating that RCAN1-4 is acting as a negative regulator in the signalling pathway mediating IL-11 expression.
Positive_regulation (mediating) of Gene_expression (expression) of IL-11
7) Confidence 0.37 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.05 Pain Relevance 0
synergistically stimulate the production of IL-11 in rheumatoid synovial fibroblasts [100].
Positive_regulation (stimulate) of Gene_expression (production) of IL-11 in fibroblasts
8) Confidence 0.13 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.80 Pain Relevance 0.49
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of Gene_expression (produce) of IL-11 in macrophages associated with cytokine
9) Confidence 0.10 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
IL-11 may represent another example of a paracrine regulatory loop, because IL-1?
Positive_regulation (because) of Gene_expression (represent) of IL-11
10) Confidence 0.10 Published 2000 Journal Arthritis Res Section Body Doc Link PMC130001 Disease Relevance 0.80 Pain Relevance 0.52
Other proinflammatory cytokines overexpressed in OA include IL-6, IL-8, IL-11, and IL-17, as well as leukotriene inhibitory factor [30].
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of IL-11 associated with osteoarthritis and cytokine
11) Confidence 0.04 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC165033 Disease Relevance 0.93 Pain Relevance 0.66
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of in neutrophils Gene_expression (produce) of IL-11 in macrophages associated with cytokine
12) Confidence 0.03 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21
Activated progenitor cells can produce numerous cytokines such as IL-6, IL-11, macrophage colony stimulating factor (M-CSF), GM-CSF and SCF.41 These cytokines can further activate more limbal stem cells, neutrophils and macrophages.
Positive_regulation (activate) of in stem cells Gene_expression (produce) of IL-11 in macrophages associated with cytokine
13) Confidence 0.03 Published 2005 Journal Yonsei Medical Journal Section Body Doc Link PMC2815811 Disease Relevance 0.49 Pain Relevance 0.21

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