INT172185

Context Info Confidence 0.23 First Reported 2002 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 5 Total Number 7 Disease Relevance 4.76 Pain Relevance 0.10

Anatomy Link Frequency T-cell 1 CHR (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammatory response 3 93.08 Calcium channel 51 54.32 Inflammatory stimuli 6 42.88 alcohol 1 34.08 Inflammation 48 30.52 imagery 12 16.08 antagonist 3 6.32 Catecholamine 18 5.00 medulla 12 5.00 cytokine 6 5.00

Disease Link Frequency Relevance Heat Carcinoma 285 100.00 Chronic Renal Failure 62 99.90 Adhesions 27 98.88 INFLAMMATION 57 92.68 Cancer 137 88.56 Anaemia 49 79.60 Renal Cancer 54 63.84 Fungal Infection 3 50.48 Shock 6 49.84 Infection 14 40.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Almost twice as many genes in Signal Transduction were increased in CC compared to Chr; a similar number were decreased in both types.

Positive_regulation (increased) of Chr associated with carcinoma

1) Confidence 0.23 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.33 Pain Relevance 0

Within Cellular and Matrix Organization and Adhesion, the expression of nearly four times as many genes was increased in CC compared to Chr, which decreased expression of about three times as many genes as did CC.

Positive_regulation (increased) of Chr associated with carcinoma and adhesions

2) Confidence 0.23 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.44 Pain Relevance 0

The data sets revealed that mRNA transcripts for CD 31 (PECAM) and the T-cell receptor beta chain were increased in CC but not Chr.

Neg (not) Positive_regulation (increased) of Chr in T-cell associated with carcinoma

3) Confidence 0.21 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.15 Pain Relevance 0

Hence, the complete sequences of CHR and CAT appear to be essential for the induction of the transient Ca2+ influx.

Positive_regulation (sequences) of CHR

4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.05 Pain Relevance 0

CHR and CAT are two antimicrobial peptides derived from CgA.

Positive_regulation (derived) of CHR

5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.09 Pain Relevance 0.05

Interestingly, the simultaneous addition of CHR and CAT at equal concentrations provoked a higher Ca2+ increase (Figure 1C) than the sum of effects observed by separately added peptides (Figure 1B and C), suggesting that CHR and CAT may have synergic effects on the transient Ca2+ entry in PMNs.

Positive_regulation (increase) of CHR

6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.05

In children with ESRD, an increase from baseline CHr levels was observed in response to oral and intravenous iron, but cut-off values for the use of CHr in the pediatric CKD population are not clear.

Positive_regulation (increase) of CHr associated with chronic renal failure

7) Confidence 0.01 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.69 Pain Relevance 0

General Comments

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