INT172185

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Context Info
Confidence 0.23
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.76
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T-cell 1
CHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 3 93.08 High High
Calcium channel 51 54.32 Quite High
Inflammatory stimuli 6 42.88 Quite Low
alcohol 1 34.08 Quite Low
Inflammation 48 30.52 Quite Low
imagery 12 16.08 Low Low
antagonist 3 6.32 Low Low
Catecholamine 18 5.00 Very Low Very Low Very Low
medulla 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 285 100.00 Very High Very High Very High
Chronic Renal Failure 62 99.90 Very High Very High Very High
Adhesions 27 98.88 Very High Very High Very High
INFLAMMATION 57 92.68 High High
Cancer 137 88.56 High High
Anaemia 49 79.60 Quite High
Renal Cancer 54 63.84 Quite High
Fungal Infection 3 50.48 Quite High
Shock 6 49.84 Quite Low
Infection 14 40.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Almost twice as many genes in Signal Transduction were increased in CC compared to Chr; a similar number were decreased in both types.
Positive_regulation (increased) of Chr associated with carcinoma
1) Confidence 0.23 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.33 Pain Relevance 0
Within Cellular and Matrix Organization and Adhesion, the expression of nearly four times as many genes was increased in CC compared to Chr, which decreased expression of about three times as many genes as did CC.
Positive_regulation (increased) of Chr associated with carcinoma and adhesions
2) Confidence 0.23 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.44 Pain Relevance 0
The data sets revealed that mRNA transcripts for CD 31 (PECAM) and the T-cell receptor beta chain were increased in CC but not Chr.
Neg (not) Positive_regulation (increased) of Chr in T-cell associated with carcinoma
3) Confidence 0.21 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.15 Pain Relevance 0
Hence, the complete sequences of CHR and CAT appear to be essential for the induction of the transient Ca2+ influx.
Positive_regulation (sequences) of CHR
4) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.05 Pain Relevance 0
CHR and CAT are two antimicrobial peptides derived from CgA.
Positive_regulation (derived) of CHR
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0.09 Pain Relevance 0.05
Interestingly, the simultaneous addition of CHR and CAT at equal concentrations provoked a higher Ca2+ increase (Figure 1C) than the sum of effects observed by separately added peptides (Figure 1B and C), suggesting that CHR and CAT may have synergic effects on the transient Ca2+ entry in PMNs.
Positive_regulation (increase) of CHR
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2639705 Disease Relevance 0 Pain Relevance 0.05
In children with ESRD, an increase from baseline CHr levels was observed in response to oral and intravenous iron, but cut-off values for the use of CHr in the pediatric CKD population are not clear.
Positive_regulation (increase) of CHr associated with chronic renal failure
7) Confidence 0.01 Published 2007 Journal Pediatr Nephrol Section Body Doc Link PMC1805051 Disease Relevance 0.69 Pain Relevance 0

General Comments

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