INT172186

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 11.63
Pain Relevance 2.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL6ST) extracellular region (IL6ST) plasma membrane (IL6ST)
Anatomy Link Frequency
adipose tissue 2
blood 1
smooth muscle cells 1
endometrium 1
decidua 1
IL6ST (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory marker 9 99.78 Very High Very High Very High
cytokine 178 98.28 Very High Very High Very High
endometriosis 148 98.12 Very High Very High Very High
antagonist 8 97.12 Very High Very High Very High
Arthritis 92 93.92 High High
rheumatoid arthritis 211 89.68 High High
Inflammation 212 88.96 High High
metalloproteinase 46 88.88 High High
COX-2 inhibitor 2 68.20 Quite High
methotrexate 116 53.84 Quite High
Disease Link Frequency Relevance Heat
Obesity 180 100.00 Very High Very High Very High
Overweight 158 100.00 Very High Very High Very High
Leukemia 19 100.00 Very High Very High Very High
INFLAMMATION 267 99.62 Very High Very High Very High
Reprotox - General 3 25 99.30 Very High Very High Very High
Endometriosis 131 98.12 Very High Very High Very High
Cancer 104 96.96 Very High Very High Very High
Carcinoma 113 96.52 Very High Very High Very High
Atherosclerosis 88 96.08 Very High Very High Very High
Endometriosis (extended) 70 94.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time PCR analysis of protocadherin-17 (PCDH17), protein tyrosine phosphatase, receptor type, R (PTPRR) and interleukin-6 signal transducer (IL6ST) expression validated the microarray findings [Table 1; [13]].
Gene_expression (expression) of interleukin-6 signal transducer
1) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2987945 Disease Relevance 0.32 Pain Relevance 0.16
Real-time PCR analysis of protocadherin-17 (PCDH17), protein tyrosine phosphatase, receptor type, R (PTPRR) and interleukin-6 signal transducer (IL6ST) expression validated the microarray findings [Table 1; [13]].
Gene_expression (expression) of IL6ST
2) Confidence 0.75 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2987945 Disease Relevance 0.32 Pain Relevance 0.16
This complex can then bind gp130, which is expressed on a much wider variety of cell types.
Gene_expression (expressed) of gp130
3) Confidence 0.64 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621374 Disease Relevance 0.47 Pain Relevance 0.19
Subsequently, we have shown that both IL-11 and GP130 mRNA expression are elevated in the late secretory phase of the menstrual cycle whereas IL-11R?
Gene_expression (expression) of GP130 mRNA
4) Confidence 0.38 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.06
and GP130; hence we investigated the potential for autocrine or paracrine signalling by localizing the sites of protein expression of GP130, IL-11R?
Gene_expression (expression) of GP130
5) Confidence 0.38 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0.05
-GP130 is often via the mitogen-activated protein kinase signalling pathways (Yin and Yang, 1994; Yang and Yin, 1995).
Gene_expression (is) of GP130
6) Confidence 0.33 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.08 Pain Relevance 0.04
Reduction of signaling by IL-6 cytokines has been associated with treatment-induced receptor protein down regulation [16,25], expression of signal modifying SOCS proteins [26] or desensitization of gp130 [27].
Gene_expression (expression) of gp130 associated with cytokine
7) Confidence 0.32 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1289280 Disease Relevance 0.06 Pain Relevance 0.23
GP130 mRNA expression was significantly elevated in the mid-late secretory phase compared with the proliferative phase of the menstrual cycle (Fig. 3E; P < 0.005; P < 0.05 respectively) but showed no significant change between first trimester decidua and pooled samples of non-pregnant endometrium (Fig. 3F).
Gene_expression (expression) of GP130 mRNA in endometrium
8) Confidence 0.29 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0 Pain Relevance 0
and GP130 expression levels in non-pregnant endometrium and first trimester decidua
Gene_expression (expression) of GP130 in decidua
9) Confidence 0.29 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.06 Pain Relevance 0
 ; GP130 forward: 5?
Gene_expression (forward) of GP130
10) Confidence 0.28 Published 2010 Journal Molecular Human Reproduction Section Body Doc Link PMC2816169 Disease Relevance 0.07 Pain Relevance 0
Tocilizumab inhibits the induction of biological activity due to IL-6 in cells that have expressed both membrane-bound IL-6R and gp130 molecules, and also inhibits the induction of biological activity due to IL-6/IL-6R complex formation in cells that express gp130 alone.
Gene_expression (express) of gp130
11) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.41 Pain Relevance 0.14
After forming a complex with IL-6, soluble (s) IL-6R can also combine with gp130 on the cell membrane and enables signaling (Ward et al 1994). s IL-6R is present in the blood of healthy individuals at a concentration of several tens of ng/mL, and if the cells express gp130, IL-6 signaling can take place, even in the absence of IL-6R expression on the cell membrane.
Gene_expression (express) of gp130 in blood
12) Confidence 0.23 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.33 Pain Relevance 0.16
Newer drugs will include interleukin-6 inhibitor/antibody, interleukin-6 receptor inhibitor/antibody, interleukin-6 antisense oligonucleotide (ASON), gp130 protein inhibitor/antibody, tyrosine kinases inhibitors/antibodies, serine/threonine kinases inhibitors/antibodies, mitogen-activated protein (MAP) kinase inhibitors/antibodies, phosphatidylinositol 3-kinase (PI3K) inhibitors/antibodies, Nuclear factor ?
Gene_expression (protein) of gp130
13) Confidence 0.18 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.75 Pain Relevance 0.16
Tocilizumab inhibits the induction of biological activity due to IL-6 in cells that have expressed both membrane-bound IL-6R and gp130 molecules, and also inhibits the induction of biological activity due to IL-6/IL-6R complex formation in cells that express gp130 alone.
Gene_expression (expressed) of gp130
14) Confidence 0.18 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727785 Disease Relevance 0.25 Pain Relevance 0.08
E-LDL accumulates in human vascular smooth muscle cells (VSMC), where it stimulates the expression of gp130, the signal-transducing chain of the IL-6 receptor (IL-6R) family, and the secretion of Interleukin-6 [83].
Gene_expression (expression) of gp130 in smooth muscle cells
15) Confidence 0.16 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.35 Pain Relevance 0
Our study also showed that EGCG enhances the synthesis of soluble gp130 protein, an endogenous inhibitor of IL-6 signaling and trans-signaling [41].
Gene_expression (synthesis) of gp130
16) Confidence 0.15 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.19 Pain Relevance 0.55
In addition to our study, where EGCG enhanced the synthesis of soluble gp130 at least in part by this mechanism, recent reports suggest that EGCG modulates alternative splicing to correct mutated proteins to normal forms, as observed for survival motor neuron-1 protein in neurodegenerative disorder, or to produce spliced variants of Mcl-1 and Bcl-X proteins in combination with ibuprofen that may inhibit the functionality of these anti-apoptotic proteins in prostate cancer cells [41,72,73].
Gene_expression (synthesis) of gp130 in motor neuron associated with apoptosis, neurodegenerative disease and reprotox - general 1
17) Confidence 0.13 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 1.21 Pain Relevance 0.15
Other inflammatory markers that were expressed at higher level in adipose tissue from overweight subjects included leptin, complement factor D (CFD), interleukin receptor 6 (IL6R), interleukin receptor 10 alpha (IL10RA), interleukin 1 receptor antagonist (IL1RN) and a number of interleukins (IL15, IL17D, IL18) (data not shown).
Gene_expression (expressed) of interleukin receptor 6 in adipose tissue associated with antagonist, inflammatory marker, obesity and overweight
18) Confidence 0.09 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.75 Pain Relevance 0.13
Other inflammatory markers that were expressed at higher level in adipose tissue from overweight subjects included leptin, complement factor D (CFD), interleukin receptor 6 (IL6R), interleukin receptor 10 alpha (IL10RA), interleukin 1 receptor antagonist (IL1RN) and a number of interleukins (IL15, IL17D, IL18) (data not shown).
Gene_expression (complement) of interleukin receptor 6 in adipose tissue associated with antagonist, inflammatory marker, obesity and overweight
19) Confidence 0.08 Published 2008 Journal Genes Nutr Section Body Doc Link PMC2593008 Disease Relevance 1.64 Pain Relevance 0.13
In the case of CD 31 and the T cell receptor beta chain, expression profiling results were concordant with immunohistochemical analysis of the tumors.
Gene_expression (expression) of cell receptor beta chain in T cell associated with cancer
20) Confidence 0.07 Published 2002 Journal BMC Bioinformatics Section Body Doc Link PMC130042 Disease Relevance 1.41 Pain Relevance 0

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