INT172197

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.61
Pain Relevance 4.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Anatomy Link Frequency
hypothalamus 2
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 271 100.00 Very High Very High Very High
Catecholamine 35 100.00 Very High Very High Very High
Pain 110 99.98 Very High Very High Very High
Lasting pain 23 98.84 Very High Very High Very High
Dopamine 149 96.68 Very High Very High Very High
Hippocampus 65 93.36 High High
monoamine 16 88.00 High High
sSRI 34 72.92 Quite High
imagery 7 63.40 Quite High
cocaine 10 58.48 Quite High
Disease Link Frequency Relevance Heat
Pain 138 99.98 Very High Very High Very High
Sprains And Strains 490 99.74 Very High Very High Very High
Disease 31 99.16 Very High Very High Very High
Cognitive Disorder 58 98.80 Very High Very High Very High
Anxiety Disorder 224 98.20 Very High Very High Very High
Alcohol Addiction 2 97.68 Very High Very High Very High
Manic Depressive Disorder 14 97.00 Very High Very High Very High
Nociception 8 96.88 Very High Very High Very High
Targeted Disruption 9 94.88 High High
Stress 16 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Collectively, these diverse mapping data sets demonstrate that expression of Comt is strongly cis-regulated and is caused by sequence variation in or around Comt itself.
Positive_regulation (caused) of Gene_expression (expression) of Comt
1) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.46 Pain Relevance 0.03
UTR is associated with higher levels of COMT protein expression.


Positive_regulation (levels) of Gene_expression (expression) of COMT protein associated with catechol-o-methyltransferase
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.39 Pain Relevance 0.17
Conversely, overexpression of human COMT containing the Val polymorphism in mice leads to the disruption of working memory and attention and a reduction in sensitivity to pain and stress [30].
Positive_regulation (overexpression) of Gene_expression (overexpression) of COMT associated with stress, pain and catechol-o-methyltransferase
3) Confidence 0.60 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.59 Pain Relevance 0.42
In the current study we observed increased expression of Comt in C57, as compared to DBA, and increased expression of 1810037I17Rik in DBA, with a very significant main effect of strain (P = 7.83 × 10-7).
Positive_regulation (increased) of Gene_expression (expression) of Comt associated with catechol-o-methyltransferase and sprains and strains
4) Confidence 0.58 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1851712 Disease Relevance 0.27 Pain Relevance 0.26
Similarly, strains with higher Comt1 expression due to the presence of a B2 SINE insertion were reported to be less sensitive to nociceptive stimuli.
Positive_regulation (due) of Gene_expression (expression) of Comt1 associated with nociception and sprains and strains
5) Confidence 0.45 Published 2010 Journal Frontiers in Neuroscience Section Body Doc Link PMC2958038 Disease Relevance 0.90 Pain Relevance 0.10
Thus, in this study, the expected pain augmenting effect of the COMT Met allele only occurred in a group of chronic pain patients.
Positive_regulation (augmenting) of Gene_expression (allele) of COMT Met associated with pain and lasting pain
6) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2964315 Disease Relevance 1.73 Pain Relevance 1.73
Variation in Comt mRNA expression and cis-regulation in CNS and peripheral tissues
Positive_regulation (Variation) of Gene_expression (expression) of Comt
7) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.80 Pain Relevance 0.09
The amplified products for each strain were purified with a PCR purification kit (Qiagen) and sequenced using both Comt 3?
Positive_regulation (sequenced) of Gene_expression (using) of Comt associated with sprains and strains
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.27 Pain Relevance 0.08
This is the first known variant in mice that causes variation in Comt expression.
Positive_regulation (causes) of Gene_expression (expression) of Comt
9) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.84 Pain Relevance 0.09
Isolation and sequencing of Comt 3?
Positive_regulation (sequencing) of Gene_expression (Isolation) of Comt
10) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923157 Disease Relevance 0.29 Pain Relevance 0.05
Catecholamine-O-methyl transferase (COMT)
Positive_regulation (Catecholamine-O-methyl transferase) of Gene_expression (Catecholamine-O-methyl transferase) of COMT associated with catecholamine
11) Confidence 0.42 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.51 Pain Relevance 0.62
The OCD-like behaviors of male ArKO mice are suggested to be caused by dysregulation of estrogen-induced catechol-O-methyltransferase (COMT) expression in the hypothalamus.
Positive_regulation (induced) of Gene_expression (expression) of COMT in hypothalamus associated with catechol-o-methyltransferase and anxiety disorder
12) Confidence 0.35 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.56 Pain Relevance 0.42

General Comments

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