INT172198

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Context Info
Confidence 0.88
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.78
Pain Relevance 3.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 165 100.00 Very High Very High Very High
Catechol-O-methyltransferase 122 100.00 Very High Very High Very High
Catecholamine 19 99.96 Very High Very High Very High
Endogenous opioid 1 99.64 Very High Very High Very High
monoamine 16 98.48 Very High Very High Very High
Morphine 56 96.28 Very High Very High Very High
gABA 14 92.84 High High
Hippocampus 23 88.96 High High
Neurotransmitter 26 79.40 Quite High
sSRI 34 67.32 Quite High
Disease Link Frequency Relevance Heat
Neurological Disease 1 97.32 Very High Very High Very High
Alcohol Addiction 5 95.84 Very High Very High Very High
Cognitive Disorder 32 95.36 Very High Very High Very High
Manic Depressive Disorder 13 95.16 Very High Very High Very High
Urological Neuroanatomy 1 93.52 High High
Aggression 15 91.76 High High
Attention Deficit Hyperactivity Disorder 51 91.24 High High
Anxiety Disorder 222 90.80 High High
Clinical Trials And Case Reports 6 88.64 High High
Sprains And Strains 185 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine.
Protein_catabolism (degradation) of Catechol-O-methyltransferase associated with catechol-o-methyltransferase and dopamine
1) Confidence 0.88 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.25 Pain Relevance 0.20
Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine.
Protein_catabolism (degradation) of COMT associated with catechol-o-methyltransferase and dopamine
2) Confidence 0.88 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.25 Pain Relevance 0.20
This disruption is likely to influence dopamine signaling since COMT is a major enzyme regulating dopamine degradation [115].
Protein_catabolism (degradation) of COMT associated with catechol-o-methyltransferase and dopamine
3) Confidence 0.74 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.67 Pain Relevance 0.45
The catechol-O-methyltransferase (COMT) gene is located on chromosome 22q11 [52] and catalyzes the degradation of catecholamines in conjuction with monoamine oxidase.
Protein_catabolism (degradation) of catechol-O-methyltransferase associated with catechol-o-methyltransferase, catecholamine and monoamine
4) Confidence 0.73 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.49 Pain Relevance 0.70
The catechol-O-methyltransferase (COMT) gene is located on chromosome 22q11 [52] and catalyzes the degradation of catecholamines in conjuction with monoamine oxidase.
Protein_catabolism (degradation) of COMT associated with catechol-o-methyltransferase, catecholamine and monoamine
5) Confidence 0.73 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.49 Pain Relevance 0.69
Catechol-O-methyltransferase (Comt), an enzyme degrading catecholamines, has been investigated as a candidate gene in many neurological disorders.
Protein_catabolism (degrading) of Catechol-O-methyltransferase associated with catechol-o-methyltransferase, neurological disease and catecholamine
6) Confidence 0.64 Published 2006 Journal BMC Genomics Section Body Doc Link PMC1553451 Disease Relevance 0.41 Pain Relevance 0.86
After release and activation of its receptors, DA undergoes dilution by diffusion, but also becomes subject to metabolic degradation by catechol-o-methyl transferase (COMT) [1], [6], [7].
Protein_catabolism (degradation) of catechol-o-methyl transferase associated with dopamine
7) Confidence 0.63 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2956650 Disease Relevance 0.22 Pain Relevance 0.50

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