INT1722

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Context Info
Confidence 0.88
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.61
Pain Relevance 3.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
upper respiratory tract 1
cleavage 1
brain 1
skin 1
meninges 1
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 20 100.00 Very High Very High Very High
bradykinin 36 99.68 Very High Very High Very High
substance P 5 99.64 Very High Very High Very High
allodynia 2 97.68 Very High Very High Very High
Hyperalgesia 2 97.12 Very High Very High Very High
Spinal cord 3 95.64 Very High Very High Very High
Pain 6 93.76 High High
Migraine 7 92.16 High High
reflex sympathetic dystrophy 1 91.20 High High
substantia gelatinosa 1 90.60 High High
Disease Link Frequency Relevance Heat
Cough 38 97.80 Very High Very High Very High
Neuropathic Pain 2 97.68 Very High Very High Very High
Hyperalgesia 2 97.12 Very High Very High Very High
Increased Venous Pressure Under Development 118 96.84 Very High Very High Very High
Hereditary Angioedema 1 88.12 High High
Lung Cancer 8 87.04 High High
Pain 6 86.84 High High
INFLAMMATION 75 85.48 High High
Neurogenic Inflammation 5 85.20 High High
Injury 8 78.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The data do not support the hypothesis that angiotensin-converting enzyme and enkephalin degrading-enzyme are identical.
Protein_catabolism (degrading-enzyme) of angiotensin-converting enzyme associated with enkephalin
1) Confidence 0.88 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 228946 Disease Relevance 0 Pain Relevance 0.33
Enkephalin-degrading enzymes and angiotensin-converting enzyme in human and rat meninges.
Protein_catabolism (degrading) of angiotensin-converting enzyme in meninges associated with enkephalin
2) Confidence 0.83 Published 1987 Journal FEBS Lett. Section Title Doc Link 3034668 Disease Relevance 0 Pain Relevance 0.51
Bradykinin is a vasodilating nonapeptide that is degraded by ACE (Hornig and Drexler 1997).
Protein_catabolism (degraded) of ACE associated with bradykinin
3) Confidence 0.65 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.41 Pain Relevance 0.47
Our findings suggest that NEP but not ACE is most important for CGRP degradation in human skin.
Protein_catabolism (degradation) of ACE in skin
4) Confidence 0.64 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 15963503 Disease Relevance 0.63 Pain Relevance 0.75
Angiotensin-converting enzyme and enkephalin-degrading enzyme activities were solubilized and purified from a particulate fraction of human diencephalon.
Protein_catabolism (degrading) of Angiotensin-converting enzyme in diencephalon associated with enkephalin
5) Confidence 0.39 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 228946 Disease Relevance 0 Pain Relevance 0.32
AngII is an octapeptide produced by cleavage of the inactive decapeptide Angiotensin I (AngI) by Angiotensin I-converting enzyme (ACE), a zinc metalloprotease found in the circulation or bound to the cell membrane.
Protein_catabolism (cleavage) of ACE in cleavage
6) Confidence 0.37 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.47 Pain Relevance 0.04
The mechanism of ACE inhibitor-induced cough remains unresolved, but likely involves the protussive mediators bradykinin and substance P, agents that are degraded by ACE and therefore accumulate in the upper respiratory tract or lung when the enzyme is inhibited [26].
Protein_catabolism (degraded) of ACE in upper respiratory tract associated with cough, bradykinin and substance p
7) Confidence 0.23 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877018 Disease Relevance 0.52 Pain Relevance 0.39
inhibit kininase II, which results in reduced degradation of
Protein_catabolism (degradation) of kininase II
8) Confidence 0.21 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.41 Pain Relevance 0.38
Because of structural similarity ACE also degrades other peptides that are substrates to this enzyme such as P substance, enkephalins, neurotensin, takynine and kininogen, the latter responsible for bradykinin generation.
Protein_catabolism (degrades) of ACE associated with enkephalin and bradykinin
9) Confidence 0.12 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 0.17 Pain Relevance 0.22
The mercaptoacetyl dipeptides (2-mercaptoacetyl-Leu-Phe and 2-mercaptoacetyl-Phe-Leu) and the N-phosphorylated dipeptides (phosphoryl-Leu-Phe and phosphoramidon) inhibited enkephalinase with IC50 values of 15, 70, 0.3 and 1 nM respectively, but were much less potent against the aminopeptidase and angiotensin converting enzyme, two other metalloenzymes implicated in the degradation of the enkephalins in brain.
Protein_catabolism (degradation) of angiotensin converting enzyme in brain associated with enkephalin
10) Confidence 0.03 Published 1983 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6352283 Disease Relevance 0 Pain Relevance 0.34

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