INT172206

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2005
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.76
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc6a3) plasma membrane (Slc6a3) transmembrane transport (Slc6a3)
Anatomy Link Frequency
striatum 2
Slc6a3 (Mus musculus)
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
midbrain 63 100.00 Very High Very High Very High
Dopamine 483 92.80 High High
Catecholamine 4 86.16 High High
Nucleus accumbens 54 82.76 Quite High
Catechol-O-methyltransferase 22 82.48 Quite High
Serotonin 68 76.20 Quite High
imagery 10 71.96 Quite High
monoamine 17 70.96 Quite High
antagonist 27 67.44 Quite High
cerebral cortex 12 63.44 Quite High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 507 100.00 Very High Very High Very High
Clinical Trials And Case Reports 3 99.52 Very High Very High Very High
Manic Depressive Disorder 4 93.44 High High
Alcohol Addiction 2 91.60 High High
Sprains And Strains 9 85.64 High High
Targeted Disruption 10 84.12 Quite High
Schizophrenia 3 55.60 Quite High
Tourette's Syndrome 1 54.68 Quite High
Anxiety Disorder 12 53.72 Quite High
Ocular Toxicity (including Many Sub-types) 33 50.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cook [48] summarized the results of an additional 11 family-based studies in a meta analysis and concluded that the association between the DAT gene and ADHD was highly significant (p < .0001).
DAT gene Binding (association) of ADHD associated with attention deficit hyperactivity disorder and clinical trials and case reports
1) Confidence 0.03 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.69 Pain Relevance 0.51
No differences were found in DRD2 or DRD4 genes but a 160 bp insertion was found in the non-coding region upstream of exon 3 of the DAT1 gene which is of significance since variable number tandem repeats in the 3'-untranslated region of the DAT gene has been associated with ADHD in several family studies [7,9,10,14,15].
DAT Binding (associated) of ADHD associated with attention deficit hyperactivity disorder
2) Confidence 0.01 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.69 Pain Relevance 0.19
Although the absence of DAT is an extreme model of reduced midbrain DAT binding in adolescents with ADHD [36] it also contrasts with several studies that found increased DAT in striatum of ADHD children and adults [10,15,35].
DAT Binding (binding) of ADHD in striatum associated with midbrain and attention deficit hyperactivity disorder
3) Confidence 0.01 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.70 Pain Relevance 0.46
Although the absence of DAT is an extreme model of reduced midbrain DAT binding in adolescents with ADHD [36] it also contrasts with several studies that found increased DAT in striatum of ADHD children and adults [10,15,35].
DAT Binding (binding) of ADHD in striatum associated with midbrain and attention deficit hyperactivity disorder
4) Confidence 0.01 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.69 Pain Relevance 0.45

General Comments

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