INT172207

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.56
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd4) plasma membrane (Drd4) cytoplasm (Drd4)
signal transducer activity (Drd4)
Anatomy Link Frequency
body 1
Drd4 (Mus musculus)
ADHD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 174 95.48 Very High Very High Very High
Clonidine 1 71.20 Quite High
Locus ceruleus 1 70.32 Quite High
Anterior cingulate cortex 2 54.04 Quite High
dopamine receptor 15 52.72 Quite High
Substantia nigra 2 38.12 Quite Low
Catechol-O-methyltransferase 22 5.00 Very Low Very Low Very Low
Neurotransmitter 15 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 34 100.00 Very High Very High Very High
Clinical Trials And Case Reports 3 98.76 Very High Very High Very High
Sprains And Strains 9 68.16 Quite High
Parkinson's Disease 5 64.20 Quite High
Movement Disorders 1 46.32 Quite Low
Anxiety Disorder 4 39.76 Quite Low
Tourette's Syndrome 1 36.88 Quite Low
Schizophrenia 3 34.72 Quite Low
Hypokinesia 1 32.08 Quite Low
Tremor 1 31.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, a formal meta analysis [32] was conducted on the growing body of literature of this DRD4 polymorphism and its association with ADHD.
DRD4 Binding (association) of ADHD in body associated with attention deficit hyperactivity disorder and clinical trials and case reports
1) Confidence 0.03 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC130047 Disease Relevance 0.43 Pain Relevance 0.29
Additionally, inheritance studies suggest an increased risk of ADHD associated with particular
   alleles of DRD4 and DRD5
   4, 40, 90. 
DRD4 Binding (associated) of ADHD associated with attention deficit hyperactivity disorder
2) Confidence 0.01 Published 2010 Journal International Journal of Biological Sciences Section Body Doc Link PMC2836544 Disease Relevance 1.12 Pain Relevance 0.19

General Comments

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