INT172213

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Context Info
Confidence 0.22
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.02
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAX, BCL2L1) cytoplasm (BAX, BCL2L1) cytosol (BAX, BCL2L1)
nucleus (BAX, BCL2L1) endoplasmic reticulum (BAX) intracellular (BCL2L1)
BAX (Homo sapiens)
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 16 98.16 Very High Very High Very High
cINOD 39 87.36 High High
Inflammation 52 10.72 Low Low
cytokine 22 6.88 Low Low
COX-2 inhibitor 104 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
metalloproteinase 8 5.00 Very Low Very Low Very Low
Paracetamol 6 5.00 Very Low Very Low Very Low
agonist 5 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 401 100.00 Very High Very High Very High
Death 87 88.16 High High
Colon Cancer 61 85.84 High High
INFLAMMATION 58 82.76 Quite High
Solid Tumor 7 66.80 Quite High
Cancer 334 61.36 Quite High
Stress 12 53.84 Quite High
Familial Adenomatous Polyposis 10 53.08 Quite High
Parkinson's Disease 1 50.40 Quite High
Breast Cancer 33 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nbk interacts with Bcl-xL and Bcl-2 but not with Bax.
Bax Binding (with) of Bcl-xL
1) Confidence 0.22 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.65 Pain Relevance 0
We have shown in the present paper that a further Bax-dependent mechanism of resveratrol-induced apoptosis may be active – aside from alterations of the Bax:Bcl-XL or Bax:Bcl-2 ratios by Bax overproduction or antagonist downregulation: the subcellular redistribution of present Bax protein.
Bax Binding (alterations) of Bcl-XL associated with antagonist and apoptosis
2) Confidence 0.08 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 1.18 Pain Relevance 0.35
Bax can form also a complex with the anti-apoptotic protein Bcl-xL [53] and Mcl-1 [14].
Bax Binding (complex) of Bcl-xL associated with apoptosis
3) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.10 Pain Relevance 0
Bax can form also a complex with the anti-apoptotic protein Bcl-xL [53] and Mcl-1 [14].
Bax Binding (form) of Bcl-xL associated with apoptosis
4) Confidence 0.04 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.10 Pain Relevance 0

General Comments

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