INT172226

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.51
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BAX) cytosol (BAX) mitochondrion (BAX)
endoplasmic reticulum (BAX) nucleus (BAX) cytoplasm (BAX)
BAX (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 1 81.60 Quite High
Pain 1 19.12 Low Low
cINOD 5 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Antiemetics 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 63 97.52 Very High Very High Very High
Apoptosis 117 95.32 Very High Very High Very High
Breast Cancer 9 65.40 Quite High
Toxicity 22 50.00 Quite Low
Colon Cancer 15 50.00 Quite Low
Necrosis 2 47.56 Quite Low
Death 27 30.92 Quite Low
Infection 1 25.76 Quite Low
Injury 1 24.88 Low Low
Pain 1 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
M resveratrol for 24 h resulted in the redistribution of Bax, regardless of p53-status, producing a distinctive, punctuate staining pattern in the cytosol with perinuclear concentration, resembling the pattern produced by the mitochondria-specific Mitotracker Red dye (Figure 2A).
Positive_regulation (resulted) of Negative_regulation (redistribution) of Bax
1) Confidence 0.48 Published 2002 Journal BMC Cancer Section Body Doc Link PMC130964 Disease Relevance 0.12 Pain Relevance 0.04
Therefore any increase in bcl-2 or decrease in bax will push the balance towards chemo resistance and an increase in bax or decrease in bcl-2 will result in increased apoptosis [26-30].
Positive_regulation (increase) of Negative_regulation (decrease) of bax associated with apoptosis
2) Confidence 0.36 Published 2004 Journal BMC Cancer Section Body Doc Link PMC514705 Disease Relevance 1.40 Pain Relevance 0

General Comments

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