INT1723

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Context Info
Confidence 0.57
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.29
Pain Relevance 1.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peroxisome (IDE) cytoplasm (IDE) signal transducer activity (IDE)
cytosol (IDE) peptidase activity (IDE) signal transduction (IDE)
Anatomy Link Frequency
cartilage 1
brain 1
diencephalon 1
IDE (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 15 100.00 Very High Very High Very High
Osteoarthritis 23 84.08 Quite High
cytokine 4 53.04 Quite High
Inflammation 17 52.16 Quite High
metalloproteinase 2 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 1 97.36 Very High Very High Very High
Osteoarthritis 23 84.08 Quite High
Aging 5 61.32 Quite High
INFLAMMATION 19 52.16 Quite High
Apoptosis 4 5.00 Very Low Very Low Very Low
Myeloid Leukemia 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiotensin-converting enzyme and enkephalin-degrading enzyme activities were solubilized and purified from a particulate fraction of human diencephalon.
Protein_catabolism (degrading) of enkephalin-degrading in diencephalon associated with enkephalin
1) Confidence 0.57 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 228946 Disease Relevance 0 Pain Relevance 0.32
The data do not support the hypothesis that angiotensin-converting enzyme and enkephalin degrading-enzyme are identical.
Protein_catabolism (degrading-enzyme) of enkephalin degrading-enzyme associated with enkephalin
2) Confidence 0.57 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 228946 Disease Relevance 0 Pain Relevance 0.33
Separation of human brain angiotensin-converting enzyme from enkephalin-degrading activity.
Protein_catabolism (degrading) of enkephalin-degrading in brain associated with enkephalin
3) Confidence 0.57 Published 1979 Journal Eur. J. Pharmacol. Section Title Doc Link 228946 Disease Relevance 0 Pain Relevance 0.46
In addition to being the most potent collagen II-degrading enzyme, MMP-13 can degrade proteoglycan and aggrecan and play a dual role in damaging cartilage matrix [44,45].
Protein_catabolism (degrade) of II-degrading enzyme in cartilage
4) Confidence 0.01 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2990994 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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