INT172307

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 6
Disease Relevance 2.66
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (TAS2R14)
TAS2R14 (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 20 98.90 Very High Very High Very High
chemokine 7 91.20 High High
sodium channel 23 86.00 High High
ASIC 25 77.72 Quite High
antagonist 6 60.24 Quite High
bradykinin 2 51.36 Quite High
abdominal pain 4 12.00 Low Low
Inflammation 2 7.40 Low Low
Opioid 3 7.12 Low Low
Somatostatin 6 6.24 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 56 99.60 Very High Very High Very High
Nicotine Addiction 68 98.66 Very High Very High Very High
Weight Loss 8 90.08 High High
Obesity 12 83.68 Quite High
Cancer 16 80.36 Quite High
Ageusia 16 53.00 Quite High
Malignant Neoplastic Disease 8 47.04 Quite Low
Rectal Cancer 4 43.12 Quite Low
Myasthenia Gravis 1 31.68 Quite Low
Lower Respiratory Tract Infection 2 27.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We did not find any other association between the TAS2R14 gene polymorphisms and the measured endpoints.


TAS2R14 gene Neg (not) Binding (association) of
1) Confidence 0.37 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2893173 Disease Relevance 0.82 Pain Relevance 0.07
We found no statistically significant association between TAS2R14 SNPs and colorectal cancer risk.
TAS2R14 Neg (no) Binding (association) of associated with colon cancer
2) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2893173 Disease Relevance 1.16 Pain Relevance 0.11
We conducted a study to investigate the hypothesis that genetic variants of TAS2R14 could influence its ability to bind bitter toxic compound, initiate the elimination of xenobiotic and thus increase the risk of colorectal cancer.
TAS2R14 Binding (bind) of associated with colon cancer
3) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2893173 Disease Relevance 0.25 Pain Relevance 0.03
Since bitter taste sensitivity has been reported to be associated with smoking and alcohol consumption [17-19], we explored at the same time the association of TAS2R14 common variants with anthropometric measures, behavioural traits like smoking and alcohol consumption and colorectal cancer susceptibility.
TAS2R14 Binding (association) of associated with nicotine addiction, colon cancer and alcohol
4) Confidence 0.36 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2893173 Disease Relevance 0.38 Pain Relevance 0.10
2), which is involved in the transduction pathways of both bitter and sweet receptors [37]; and a bitter taste receptor activated by multiple ligands, T2R14 [38].
T2R14 Binding (ligands) of
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754526 Disease Relevance 0.05 Pain Relevance 0.12
Adrenomedullin has now been shown to bind a family-B receptor and is discussed further below.
family-B receptor Binding (bind) of
6) Confidence 0.03 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.15

General Comments

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