INT172328

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2002
Negated 1
Speculated 1
Reported most in Body
Documents 1
Total Number 55
Disease Relevance 61.51
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
kidney 3
middle ear 1
ganglion cells 1
lacuna 1
vascular component 1
Phl1 (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 110 99.68 Very High Very High Very High
imagery 220 96.24 Very High Very High Very High
corticosteroid 55 95.44 Very High Very High Very High
medulla 55 95.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Deafness 4235 100.00 Very High Very High Very High
Hearing Impairment 385 100.00 Very High Very High Very High
Sensorineural Hearing Loss 385 100.00 Very High Very High Very High
Mixed Conductive-sensorineural Hearing Loss 110 100.00 Very High Very High Very High
Conductive Hearing Loss 110 100.00 Very High Very High Very High
High-frequency Hearing Loss 55 100.00 Very High Very High Very High
Fabry Disease 1760 99.92 Very High Very High Very High
Sudden Hearing Loss 1045 99.92 Very High Very High Very High
Left Ventricular Hypertrophy 880 99.80 Very High Very High Very High
Stroke 220 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figure 1 illustrates the degree of hearing loss of each subject as a function of age (n = 22 subjects).
Negative_regulation (loss) of hearing associated with deafness
1) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.71 Pain Relevance 0
Most of patients after 41 years of age had a mild to profound hearing loss.
Negative_regulation (loss) of hearing associated with deafness
2) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.73 Pain Relevance 0
Configuration of hearing loss was classified according to the European Working Group on Genetics of Hearing Impairment.
Negative_regulation (loss) of hearing associated with deafness and hearing impairment
3) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.27 Pain Relevance 0
In our patients, the hearing loss was present in most cases before dialysis or transplant.
Negative_regulation (loss) of hearing associated with deafness
4) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.22 Pain Relevance 0
Sudden sensory hearing loss
Negative_regulation (loss) of hearing associated with deafness
5) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.08 Pain Relevance 0.04
Both patients demonstrated a bilateral sloping sensorineural hearing loss.
Negative_regulation (loss) of hearing associated with sensorineural hearing loss
6) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.41 Pain Relevance 0
For correlation with hearing loss, the cerebrovascular involvement was classified into either absence or presence of any neurological clinical symptoms (strokes, transient ischaemic attacks) or magnetic resonance imaging (MRI) lesions (leukoareiosis or lacuna).
Negative_regulation (loss) of hearing in lacuna associated with brain hemorrhage, deafness, stroke and imagery
7) Confidence 0.03 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.22 Pain Relevance 0.13
No conductive or mixed hearing loss was observed.
Neg (No) Negative_regulation (loss) of hearing associated with mixed conductive-sensorineural hearing loss
8) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.13 Pain Relevance 0
The type of hearing loss (HL) was classified as sensorineural, conductive, or mixed according to the European Working Group on Genetics of Hearing Impairment .
Negative_regulation (loss) of hearing associated with deafness and hearing impairment
9) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.97 Pain Relevance 0.05
In our study, no patient had conductive hearing loss, and all patients had type A tympanograms, in favor of normal middle ear mobility and pressure.
Negative_regulation (loss) of hearing in middle ear associated with conductive hearing loss
10) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.68 Pain Relevance 0
Sudden deafness may be defined as a sensorineural hearing loss that develops over a period of hours or a few days.
Negative_regulation (loss) of hearing associated with sensorineural hearing loss and sudden hearing loss
11) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.16 Pain Relevance 0.04
The degree of hearing loss was categorized in two different ways: employment of commonly used age-independent clinical guidelines (International classification of impairments, disabilities and handicaps, World Health Organization, May 1980, Geneva, Switzerland) and comparison of thresholds to age-dependant percentiles [9,10].
Negative_regulation (loss) of hearing associated with deafness
12) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.06 Pain Relevance 0.04
One paper reported the histology of temporal bones in two patients [6], whose audiograms exhibited a bilateral sensorineural hearing loss audiometrically.
Negative_regulation (loss) of hearing in temporal bones associated with sensorineural hearing loss
13) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.90 Pain Relevance 0
Audiometric configurations of the remaining audiograms (n = 21), according to the European Work Group on Genetics of Hearing Impairment, were mid-frequency U-shaped (n = 1), flat (n = 4), high-frequency hearing loss (n = 13), and cophosis (n = 3).
Negative_regulation (loss) of hearing associated with deafness and hearing impairment
14) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.74 Pain Relevance 0
To identify the contribution of Fabry disease to the observed sensorineural hearing loss, audiometric thresholds at 0.5, 1, 2, 4 and 8 kHz, as well as PTAs, were compared to those reported for an audiologically screened population 25 years and older [9,10].
Negative_regulation (loss) of hearing associated with sensorineural hearing loss and fabry disease
15) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 0.60 Pain Relevance 0
Patients affected with Fabry disease have an increased incidence of progressive hearing loss and sudden deafness: an investigation of twenty-two hemizygous male patients

Background

Negative_regulation (loss) of hearing associated with deafness, fabry disease and sudden hearing loss
16) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Title Doc Link PMC134464 Disease Relevance 0.62 Pain Relevance 0
Age-independent analysis of hearing loss
Negative_regulation (loss) of hearing associated with deafness
17) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.26 Pain Relevance 0
We observed a positive correlation between hearing loss and cerebrovascular accidents in our cohort of FD patients, further emphasising the importance of the vascular component as a likely mechanism for the occurrence of deafness in FD.
Negative_regulation (loss) of hearing in vascular component associated with deafness, stroke and fabry disease
18) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.90 Pain Relevance 0
Otoacoustic emissions (i.e., distortion product and transient-evoked otoacoustic emissions) were tested in all subjects, and revealed responses that were consistent with the degree of hearing loss [12,13].
Negative_regulation (loss) of hearing associated with deafness
19) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.72 Pain Relevance 0
Most patients with hearing loss had a decreased glomerular filtration rate.
Negative_regulation (loss) of hearing associated with deafness
20) Confidence 0.02 Published 2002 Journal BMC Med Genet Section Body Doc Link PMC134464 Disease Relevance 1.26 Pain Relevance 0

General Comments

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