INT172329

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.88
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (MRC1) plasma membrane (MRC1)
Anatomy Link Frequency
macrophage 1
joint 1
germline 1
MLH1 1
MRC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 15 53.12 Quite High
abdominal pain 4 37.76 Quite Low
Central nervous system 16 21.20 Low Low
metalloproteinase 5 11.24 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Enkephalin 4 5.00 Very Low Very Low Very Low
substance P 4 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Togavirus Infection 53 100.00 Very High Very High Very High
Hereditary Nonpolyposis Colorectal Neoplasms 12 98.12 Very High Very High Very High
Fever 1 97.24 Very High Very High Very High
Colorectal Cancer 50 96.24 Very High Very High Very High
Microsatellite Instability 50 95.24 Very High Very High Very High
Dengue 15 94.28 High High
Infection 71 93.88 High High
Carcinoma 77 89.16 High High
Immunization 14 85.08 High High
Syndrome 63 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The trial is being conducted in practices recruited through the MRC GP Research Framework with list sizes of between 200 and 700 patients aged 75 years and over and selected to be representative of the joint tertiles of Jarman and Standard Mortality Ratios (SMRs) in UK practices.
MRC Binding (recruited) of in joint
1) Confidence 0.36 Published 2002 Journal BMC Health Serv Res Section Body Doc Link PMC134467 Disease Relevance 0 Pain Relevance 0
Older age at biopsy was associated with a longer MMR-biopsy interval, independent of case status (Spearman rank correlation, Rho?
MMR Binding (associated) of associated with togavirus infection
2) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2526159 Disease Relevance 0.84 Pain Relevance 0
Mammalian mismatch repair (MMR) genes encode for nine proteins (MLH1, MLH3, PMS1, PMS2, MSH2, MSH3, MSH4, MSH5, and MSH6) that interact with each other to form complexes and heterodimers that mediate distinct functions in MMR-related system.
MMR Binding (interact) of in MLH1
3) Confidence 0.08 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2846683 Disease Relevance 1.15 Pain Relevance 0
The MMR genes mutated in the germline in HNPCC have been identified so far as hMSH2 (located on 2p), hMLH1 (located on 3p), hPMS1, hPMS2 and hMSH6.
MMR Binding (germline) of in germline
4) Confidence 0.07 Published 2008 Journal Current Genomics Section Body Doc Link PMC2674304 Disease Relevance 1.27 Pain Relevance 0
To our knowledge, we show for the first time that the MØ mannose receptor (MR) binds to all four serotypes of DV and specifically to the envelope glycoprotein.
mannose receptor Binding (binds) of
5) Confidence 0.02 Published 2008 Journal PLoS Pathogens Section Abstract Doc Link PMC2233670 Disease Relevance 0.50 Pain Relevance 0.03
This could be either be due to M6P directly binding to the mannose receptor or to incomplete phosphorylation, leaving some mannose residues intact, which may then bind to mannose receptor.
mannose receptor Binding (binding) of
6) Confidence 0.01 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0
This could be either be due to M6P directly binding to the mannose receptor or to incomplete phosphorylation, leaving some mannose residues intact, which may then bind to mannose receptor.
mannose receptor Binding (bind) of
7) Confidence 0.01 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0
From an ERT point of view, this is undesirable, because the higher sugars will obscure the mannoses and prevent mannose receptor binding.
mannose receptor Binding (binding) of
8) Confidence 0.01 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0 Pain Relevance 0
GILT-bearing constructs are not as efficiently cleared from the bloodstream as M6P-bearing constructs, presumably because they do not bind macrophage mannose receptor.
mannose receptor Neg (not) Spec (cleared) Binding (bind) of in macrophage
9) Confidence 0.01 Published 2009 Journal Microb Cell Fact Section Body Doc Link PMC2674406 Disease Relevance 0.11 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox