INT17234

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Context Info
Confidence 0.45
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.66
Pain Relevance 4.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (PDYN) extracellular region (PDYN) plasma membrane (PDYN)
Anatomy Link Frequency
myocardium 2
neurons 2
anterior pituitary 2
PDYN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 28 100.00 Very High Very High Very High
Dynorphin 9 100.00 Very High Very High Very High
Nicotine 7 99.88 Very High Very High Very High
Paracetamol 2 99.84 Very High Very High Very High
antagonist 17 99.72 Very High Very High Very High
opioid receptor 29 99.48 Very High Very High Very High
Inflammation 4 97.26 Very High Very High Very High
substance P 5 97.20 Very High Very High Very High
Hyperalgesia 1 96.36 Very High Very High Very High
Antinociceptive 6 94.88 High High
Disease Link Frequency Relevance Heat
Arrhythmias 2 Under Development 4 98.60 Very High Very High Very High
INFLAMMATION 5 97.26 Very High Very High Very High
Hyperalgesia 1 96.36 Very High Very High Very High
Myocardial Infarction 1 75.00 Quite High
Nociception 5 55.44 Quite High
Inflammatory Pain 3 42.64 Quite Low
Pain 7 41.24 Quite Low
Overdose 1 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ventricular fibrillation, caused by the occlusion of the anterior descending coronary artery, results in leu-enkephalin level decrease in ischemic and non-ischemic zones of myocardium.
Positive_regulation (results) of Negative_regulation (decrease) of leu-enkephalin in myocardium associated with arrhythmias 2 under development and enkephalin
1) Confidence 0.45 Published 1988 Journal Biull Eksp Biol Med Section Abstract Doc Link 2847826 Disease Relevance 0.34 Pain Relevance 0.34
On the other hand, the hyperalgesia, as a consequence of peripheral inflammation induced by a variety of agents, is associated with increased dynorphin expression [18-20], and opioid receptor antagonists reversed the decrease in dynorphin level induced by paracetamol [21].
Positive_regulation (induced) of Negative_regulation (decrease) of dynorphin associated with paracetamol, hyperalgesia, dynorphin, inflammation, antagonist and opioid receptor
2) Confidence 0.45 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000619 Disease Relevance 0.32 Pain Relevance 1.75
Nicotine also increased native Met-enkephalin in jejunum, decreased cryptic Met-enkephalin in heart atrium, increased native Leu-enkephalin in anterior pituitary and decreased cryptic Leu-enkephalin in jejunum.
Positive_regulation (increased) of Negative_regulation (decreased) of Leu-enkephalin in anterior pituitary associated with nicotine and enkephalin
3) Confidence 0.23 Published 1991 Journal Neuropeptides Section Abstract Doc Link 1891072 Disease Relevance 0 Pain Relevance 1.83
Dynorphin mRNA is found in the caudate and putamen, preferentially in the patch neurons; nevertheless, a low level of dynorphin mRNA is also present in neurons of the caudate matrix.
Positive_regulation (present) of Negative_regulation (level) of dynorphin mRNA in neurons associated with dynorphin
4) Confidence 0.13 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 8543654 Disease Relevance 0 Pain Relevance 0.97

General Comments

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