INT172368

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 1999
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
chondrocytes 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 1 98.48 Very High Very High Very High
cytokine 9 85.68 High High
antagonist 3 67.80 Quite High
Dopamine 3 57.92 Quite High
imagery 12 13.84 Low Low
Inflammation 30 5.00 Very Low Very Low Very Low
Somatostatin 19 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Osteoarthritis 7 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 99.68 Very High Very High Very High
Acromegaly 83 99.28 Very High Very High Very High
Cancer 39 98.50 Very High Very High Very High
Critical Illness 19 89.36 High High
Disease 19 80.20 Quite High
Arthropathy 12 79.60 Quite High
Wound Healing 1 76.04 Quite High
Burns 6 74.64 Quite High
Recurrence 2 74.52 Quite High
Pituitary Cancer 18 73.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another approach was described by De Ceuninck et al [55], who noted that disruption of IGF-1 binding to the inhibitory binding proteins via small molecules, resulting in the release of free IGF-1, restores the anabolic response of human chondrocytes.
Negative_regulation (disruption) of IGF-1 Binding (binding) of in chondrocytes
1) Confidence 0.42 Published 2006 Journal BMC Complement Altern Med Section Body Doc Link PMC1456997 Disease Relevance 0.15 Pain Relevance 0.08
Tumor excision, usually by the trans-sphenoidal route, is the most rapid way of reducing GH and IGF-I concentrations in patients with acromegaly.
Negative_regulation (reducing) of IGF-I Binding (concentrations) of associated with acromegaly and cancer
2) Confidence 0.35 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2459162 Disease Relevance 0.83 Pain Relevance 0.06
IGF-1 and its binding protein, IGF binding protein-3, are both reduced during stress [79].
Negative_regulation (reduced) of IGF-1 Binding (binding protein) of associated with stress
3) Confidence 0.10 Published 1999 Journal Crit Care Section Body Doc Link PMC137235 Disease Relevance 0.59 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox