INT17237

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Context Info
Confidence 0.43
First Reported 1980
Last Reported 2010
Negated 6
Speculated 5
Reported most in Body
Documents 74
Total Number 80
Disease Relevance 49.09
Pain Relevance 17.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Esr1) DNA binding (Esr1) protein complex (Esr1)
cytoplasm (Esr1) lipid binding (Esr1) nucleus (Esr1)
Anatomy Link Frequency
reticulum 2
retina 1
erythrocyte 1
TMJ 1
cell body 1
Esr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Arthritis 500 100.00 Very High Very High Very High
agonist 188 100.00 Very High Very High Very High
Serotonin 372 99.84 Very High Very High Very High
spinal inflammation 29 99.72 Very High Very High Very High
Paracetamol 13 99.54 Very High Very High Very High
Pain 146 99.52 Very High Very High Very High
backache 57 99.40 Very High Very High Very High
methotrexate 482 99.28 Very High Very High Very High
gABA 3 99.24 Very High Very High Very High
Inflammation 580 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 459 100.00 Very High Very High Very High
Stress 296 100.00 Very High Very High Very High
Experimental Arthritis 248 100.00 Very High Very High Very High
Multiple Sclerosis 36 100.00 Very High Very High Very High
Congenital Anomalies 26 100.00 Very High Very High Very High
Cancer 729 99.96 Very High Very High Very High
Arthritis 243 99.88 Very High Very High Very High
Syndrome 31 99.86 Very High Very High Very High
Reperfusion Injury 2 99.76 Very High Very High Very High
Breast Cancer 217 99.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The estrogen-mediated suppression of inflammation and joint destruction in murine CIA is dependent on ER?
Regulation (dependent) of ER in joint associated with inflammation and arthritis
1) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.93 Pain Relevance 0.25
The aim of this study was to investigate the role of common polymorphisms in the estrogen receptor gene (ESR1) and the progesterone receptor gene (PGR) in the risk for migraine in a Spanish population.
Spec (investigate) Regulation (role) of ESR1 associated with migraine
2) Confidence 0.40 Published 2009 Journal Eur. J. Neurol. Section Abstract Doc Link 19175383 Disease Relevance 0.27 Pain Relevance 0.27
Both ERalpha and ERbeta agonists modulate striatal preproenkephalin (PPE) gene expression in ovariectomized rats.
Regulation (modulate) of ERalpha associated with agonist
3) Confidence 0.38 Published 2008 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17936613 Disease Relevance 0.66 Pain Relevance 0.46
Next, effects of ER agonists (ethinyl-estradiol, an ER?
Regulation (effects) of ER associated with agonist
4) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911889 Disease Relevance 1.19 Pain Relevance 0.64
We used the synthetic estrogen EE, synthesized in house, at dosages that have been described to be orally effective in the treatment of EAE and CIA [23,26] The pharmacologic properties for the ER?
Regulation (effective) of ER associated with multiple sclerosis and arthritis
5) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.91 Pain Relevance 0.56
Next, effects of ER agonists (ethinyl-estradiol, an ER?
Regulation (effects) of ER associated with agonist
6) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2911889 Disease Relevance 1.21 Pain Relevance 0.65
In ER-positive human breast cancer, a selective estrogen receptor modulator (SERM), tamoxifen, is typically used in adjuvant therapy.
Regulation (modulator) of estrogen receptor associated with breast cancer
7) Confidence 0.37 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.90 Pain Relevance 0.04
were significantly downregulated in both BALB/c MPA-treated and progesterone-treated mice, and it is interesting to note that ER-?
Regulation (note) of ER
8) Confidence 0.33 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1868922 Disease Relevance 0.39 Pain Relevance 0
To demonstrate the utility of this model in antiestrogen therapy, we treated the animals with tamoxifen, the gold standard and FDA-approved adjuvant therapeutic for ER-positive cancer, and a less extensively studied SERM, ospemifene.
Regulation (therapeutic) of ER-positive associated with cancer
9) Confidence 0.32 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.13 Pain Relevance 0.07
expression, differential ER conformation on ligand binding, and differential expression and binding to the ER of coregulator proteins (coactivators or corepressors).
Regulation (differential) of ER
10) Confidence 0.30 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2643104 Disease Relevance 0.64 Pain Relevance 0.27
allowing for ER cross regulation and signaling in context.
Regulation (regulation) of ER
11) Confidence 0.26 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911889 Disease Relevance 0.83 Pain Relevance 0.23
An ESR taken without an aim, or when somatic disease is unlikely, is of little or no clinical value.
Neg (no) Regulation (value) of ESR associated with disease
12) Confidence 0.23 Published 1991 Journal Scand J Prim Health Care Section Abstract Doc Link 1891664 Disease Relevance 0.23 Pain Relevance 0
Abnormalities include alterations in endoplasmic reticulum (ER) chaperone protein expression, indicative of an ER stress response.
Regulation (response) of ER in reticulum associated with stress and congenital anomalies
13) Confidence 0.20 Published 2008 Journal Exp. Cell Res. Section Abstract Doc Link 18638474 Disease Relevance 0.60 Pain Relevance 0.12
-cells during fetal and neonatal development and not because of uncontrolled ER stress[11].
Regulation (uncontrolled) of ER associated with stress
14) Confidence 0.20 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.22 Pain Relevance 0
The widely accepted UPR model predicts that loss of PERK function results in uncontrolled translation leading to ER protein overload, up-regulation of the transcriptional arm of the ER-stress response and ultimately cell death [2].
Regulation (regulation) of ER in arm associated with stress and death
15) Confidence 0.20 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.12 Pain Relevance 0.19
In this study we also found that the exocrine pancreatic atrophy in PERK-deficient mice is inconsistent with the hypothesis that it is caused by uncontrolled or dysfunctional regulation of ER stress.
Regulation (regulation) of ER associated with stress and frailty
16) Confidence 0.20 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2072952 Disease Relevance 1.32 Pain Relevance 0.03
To further clarify the participation of ER stress, we examined the changes in BiP and CHOP in the retina after NMDA-induced injury.
Regulation (participation) of ER in retina associated with stress and injury
17) Confidence 0.20 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2652022 Disease Relevance 1.18 Pain Relevance 0.07
These differences in ER modulation may suggest different mechanisms of action between the two related SERMs and may portend different long-term outcomes.
Regulation (modulation) of ER
18) Confidence 0.19 Published 2005 Journal Breast Cancer Res Section Abstract Doc Link PMC1410776 Disease Relevance 0.88 Pain Relevance 0.03
Therefore, these differences in ER modulation between the two related SERMs may suggest different mechanisms of action and may portend different long-term outcomes.
Regulation (modulation) of ER
19) Confidence 0.19 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1410776 Disease Relevance 1.18 Pain Relevance 0
MTX responder: defined as patients who fulfilled three criteria—physician statement of good response and ESR ?
Regulation (fulfilled) of ESR associated with methotrexate
20) Confidence 0.19 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2468887 Disease Relevance 0.39 Pain Relevance 0.42

General Comments

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