INT1724

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Context Info
Confidence 0.59
First Reported 1979
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 437
Total Number 443
Disease Relevance 315.64
Pain Relevance 74.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
heart 21
blood 17
coronary artery 8
endothelium 6
plasma 5
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1434 100.00 Very High Very High Very High
bradykinin 1018 100.00 Very High Very High Very High
antagonist 834 100.00 Very High Very High Very High
beta blocker 966 99.96 Very High Very High Very High
ischemia 501 99.96 Very High Very High Very High
aspirin 424 99.96 Very High Very High Very High
alcohol 162 99.96 Very High Very High Very High
Potency 51 99.96 Very High Very High Very High
cINOD 201 99.92 Very High Very High Very High
anesthesia 35 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1647 100.00 Very High Very High Very High
Hypertension 6707 99.98 Very High Very High Very High
Myocardial Infarction 3099 99.96 Very High Very High Very High
Cv Unclassified Under Development 499 99.96 Very High Very High Very High
Increased Venous Pressure Under Development 1564 99.92 Very High Very High Very High
Vasculitis 87 99.92 Very High Very High Very High
Diabetes Mellitus 9876 99.90 Very High Very High Very High
Impaired Glucose Tolerance 273 99.88 Very High Very High Very High
Appetite Loss 226 99.88 Very High Very High Very High
Cancer 2064 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A 50-year-old very obese man had suffered from hypertension for more than 20 years and had undergone various treatment regimens, the last being with an ACE inhibitor.
Negative_regulation (inhibitor) of ACE associated with hypertension and obesity
1) Confidence 0.59 Published 1995 Journal Fortschr. Med. Section Abstract Doc Link 7607592 Disease Relevance 0.63 Pain Relevance 0.14
A safer way of producing therapeutic effects is promised by the delivery of the ACE antisense sequences by a vector producing a permanent inhibition of ACE and long-term control of blood pressure in hypertensive patients.
Negative_regulation (inhibition) of ACE in blood associated with hypertension
2) Confidence 0.59 Published 2003 Journal Curr. Pharm. Des. Section Abstract Doc Link 12570787 Disease Relevance 0.67 Pain Relevance 0.17
Skeletal muscle metabolic efficiency is reduced in patients with heart failure and is improved by ACE inhibition.
Negative_regulation (inhibition) of ACE in heart associated with myocardial infarction
3) Confidence 0.59 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15686789 Disease Relevance 0.52 Pain Relevance 0.17
Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers for the prevention of migraines.
Negative_regulation (inhibitors) of Angiotensin-converting enzyme associated with migraine disorders
4) Confidence 0.59 Published 2010 Journal Ann Pharmacother Section Title Doc Link 20086184 Disease Relevance 0.10 Pain Relevance 0.09
The fetal hemodynamic parameters may be affected by captopril administration to the mother: blood pressure falls, plasma renin activity increases, ACE activity decreases.
Negative_regulation (decreases) of ACE in plasma
5) Confidence 0.59 Published 1989 Journal Dev Pharmacol Ther Section Abstract Doc Link 2693003 Disease Relevance 0.19 Pain Relevance 0.36
However, the prescribing information for ACE inhibitors does not discourage their use in either cancer or PUD and univariate analysis shows no significant differences between the number of comorbidities in ACE inhibitor users and non-users.
Negative_regulation (inhibitors) of ACE associated with cancer and peptic ulcer disease
6) Confidence 0.58 Published 2008 Journal BMC Endocr Disord Section Body Doc Link PMC2632632 Disease Relevance 1.17 Pain Relevance 0.24
The purified enzymes had markedly different sensitivities to known inhibitors of angiotensin-converting enzyme.
Negative_regulation (inhibitors) of angiotensin-converting enzyme
7) Confidence 0.58 Published 1979 Journal Eur. J. Pharmacol. Section Abstract Doc Link 228946 Disease Relevance 0 Pain Relevance 0.34
The biofunctional peptide activity currently most studied in food proteins appears to be those that inhibit ACE.
Negative_regulation (inhibit) of ACE
8) Confidence 0.58 Published 2007 Journal Curr. Pharm. Des. Section Abstract Doc Link 17430180 Disease Relevance 0.09 Pain Relevance 0.21
It would therefore be interesting to evaluate further alpha-2 adrenoceptor agonists and ACE inhibitors in a combination therapy in humans when single drug antihypertensive therapy of the drugs is insufficient.
Negative_regulation (inhibitors) of ACE associated with agonist
9) Confidence 0.58 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2898524 Disease Relevance 0.66 Pain Relevance 0.43
Then peptide substrates were used to inhibit ACE hydrolyzing Fa-Phe-Gly-Gly and NEP cleaving Leu(5)-enkephalin.
Negative_regulation (inhibit) of ACE associated with enkephalin
10) Confidence 0.58 Published 2004 Journal Peptides Section Abstract Doc Link 15134871 Disease Relevance 0.06 Pain Relevance 0.82
The first inhibitor of angiotensin converting enzyme (ACE) was found in and isolated from the venom of the South American pit viper Bothrops jararaca.
Negative_regulation (inhibitor) of angiotensin converting enzyme in pit
11) Confidence 0.58 Published 1988 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2466391 Disease Relevance 0.50 Pain Relevance 0.16
The first inhibitor of angiotensin converting enzyme (ACE) was found in and isolated from the venom of the South American pit viper Bothrops jararaca.
Negative_regulation (inhibitor) of ACE in pit
12) Confidence 0.58 Published 1988 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2466391 Disease Relevance 0.50 Pain Relevance 0.16
Accumulation of bradykinin via inhibition of ACE may increase NO synthesis or activity, resulting in improved vasodilative response.
Negative_regulation (inhibition) of ACE associated with bradykinin
13) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 0.30 Pain Relevance 0.19
The underlying rationale for the study was that the inhibition of ACE would prevent events related to ischemia and atherosclerosis; the study therefore included a broad range of patients with any atherosclerosis manifestation: coronary artery disease (CAD), history of CVD or peripheral vascular disease, or diabetes and one cardiovascular risk factor; ramipril was beneficial in all these subgroups.
Negative_regulation (inhibition) of ACE in coronary artery associated with coronary artery disease, diabetes mellitus, cardiovascular disease, atherosclerosis, ischemia and peripheral arterial disease
14) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 1.50 Pain Relevance 0.11
The benefits of ramipril were observed among patients who were already taking a number of effective treatments, such as aspirin, beta-blockers and lipid lowering agents, indicating that the inhibition of ACE offers an additional approach to the prevention of atherothrombotic complications.
Negative_regulation (inhibition) of ACE associated with aspirin and beta blocker
15) Confidence 0.58 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 1.28 Pain Relevance 0.14
[Activation of bradykinin formation cascade on receiving autologous blood transfusion through a white cell-reduction filter in a patient treated with an ACE inhibitor].
Negative_regulation (inhibitor) of ACE in blood associated with bradykinin
16) Confidence 0.57 Published 1998 Journal Masui Section Title Doc Link 9560545 Disease Relevance 0.19 Pain Relevance 0.35
Intracoronary blockade of angiotensin-converting enzyme in humans: interaction with cardiac sympathetic neurotransmission?
Negative_regulation (blockade) of angiotensin-converting enzyme in sympathetic
17) Confidence 0.57 Published 1997 Journal Acta Physiol. Scand. Section Title Doc Link 9381945 Disease Relevance 0.16 Pain Relevance 0.21
Four subjects took hydrochlorothiazide, three took an ACE inhibitor, two took an angiotensin II receptor blocker, and one each took a ?
Negative_regulation (inhibitor) of ACE
18) Confidence 0.57 Published 2008 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2570577 Disease Relevance 0.08 Pain Relevance 0.05
One excellent example of successful drug development from a component of snake venom (Bothrops jararaca [Wied 1824]) is that of the inhibitors of angiotensin-converting enzyme (ACE).
Negative_regulation (inhibitors) of ACE
19) Confidence 0.57 Published 2007 Journal J Ethnobiol Ethnomedicine Section Body Doc Link PMC1847427 Disease Relevance 0.07 Pain Relevance 0
However, the antioxidant alpha-lipoic acid, as well as compounds which correct vascular dysfunction and hence neuropathy, such as ACE inhibitors and protein kinase C-beta inhibitors, have demonstrated more success.
Negative_regulation (inhibitors) of ACE associated with kinase c and neuropathic pain
20) Confidence 0.57 Published 2003 Journal Treat Endocrinol Section Abstract Doc Link 15981943 Disease Relevance 0.67 Pain Relevance 0.61

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