INT17243

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Context Info
Confidence 0.55
First Reported 1984
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 4.70
Pain Relevance 2.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 6
chest 2
endothelium 2
smooth muscle cells 2
Tbxa2r (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 3 100.00 Very High Very High Very High
Angina 12 99.04 Very High Very High Very High
Clonidine 8 98.00 Very High Very High Very High
ischemia 2 96.20 Very High Very High Very High
cva 9 93.60 High High
peripheral neuropathy 1 90.48 High High
Pain 1 89.60 High High
local anesthetic 3 87.84 High High
aspirin 1 87.00 High High
cINOD 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 14 100.00 Very High Very High Very High
INFLAMMATION 5 100.00 Very High Very High Very High
Myocardial Infarction 12 99.82 Very High Very High Very High
Thrombosis Related Under Development 1 99.52 Very High Very High Very High
Angina 1 99.04 Very High Very High Very High
Cv General 3 Under Development 14 98.68 Very High Very High Very High
Hemorrhage 1 98.52 Very High Very High Very High
Diabetes Mellitus 5 97.04 Very High Very High Very High
Coronary Artery Disease 2 96.20 Very High Very High Very High
Syndrome 4 94.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results show that TXA2 produced in smooth muscle cells is increased in mesenteric arteries from orchidectomized rats compared to their controls, and that this prostanoid is functionally involved in the vasoconstrictor response to clonidine only in arteries from the orchidectomized rats.
Positive_regulation (increased) of Gene_expression (produced) of TXA2 in smooth muscle cells associated with clonidine
1) Confidence 0.55 Published 2006 Journal J. Vasc. Res. Section Abstract Doc Link 16293968 Disease Relevance 0 Pain Relevance 0.64
Although MK-447 alone at 1 and 10 microM had no significant effects, MK-447 at 100 microM stimulated both PGI2 and TXA2 biosynthesis, and suppressed the lipid peroxidation in the pulp tissue as estimated by thiobarbituric acid method.
Positive_regulation (stimulated) of Gene_expression (biosynthesis) of TXA2
2) Confidence 0.50 Published 1985 Journal Biochem. Pharmacol. Section Abstract Doc Link 3921031 Disease Relevance 0.16 Pain Relevance 0.12
Plasma levels of thromboxane A2 (TXA2), an inflammatory mediator inducing platelet aggregation, bronchoconstriction, and vasoconstriction, are increased in the perioperative period.
Positive_regulation (increased) of Gene_expression (levels) of thromboxane A2 in platelet associated with inflammation and increased venous pressure under development
3) Confidence 0.42 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15281511 Disease Relevance 0.54 Pain Relevance 0.35
The evidence favouring the role of platelets is: 1) the aggregability of platelets is increased in the morning where the incidence of MI and sudden cardiac death has been shown to be high, 2) shortened bleeding time and increased mean platelet volume in the acute phase of MI, 3) the synthesis of proaggregatory thromboxane A2 is increased in the acute phase of MI and in UAP, 4) a high platelet count and an increased ADP-induced platelet aggregation predispose to MI and death in healthy males, 5) high mean platelet volume and increased spontaneous platelet aggregation are risk factors for MI and death in patients with a recent MI, 6) the platelet inhibitor, acetylsalicylic acid, has been shown to reduce the incidence of MI and mortality in patients with silent myocardial ischaemia, stable and unstable angina pectoris and in patients with MI.
Positive_regulation (increased) of Gene_expression (synthesis) of thromboxane A2 in platelets associated with aspirin, angina, coronary artery disease, hemorrhage, death and myocardial infarction
4) Confidence 0.37 Published 1995 Journal Ugeskr. Laeg. Section Abstract Doc Link 7652964 Disease Relevance 2.36 Pain Relevance 0.53
On the other hand, the cerebrovascular endothelium is not likely to be the only source of TXA2 release since L-NAME induced vasomotion in only 3 out of 32 isolated MCAs in vitro, suggesting that vascular TXA2 production by itself may not be sufficient to evoke vasomotion even in case of diminished NO synthesis.
Positive_regulation (vascular) of Gene_expression (production) of TXA2 in endothelium
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013104 Disease Relevance 0.41 Pain Relevance 0.06
There was also increased thromboxane B2 (TXB2) production after platelet stimulation by NaAA.
Positive_regulation (increased) of Gene_expression (production) of thromboxane B2 in platelet
6) Confidence 0.01 Published 1984 Journal Clin. Sci. Section Abstract Doc Link 6434224 Disease Relevance 0.44 Pain Relevance 0.13
Thus, the biosynthesis of thromboxane A2, which is largely derived from activated platelets, is increased, often coincident with chest pain.
Positive_regulation (increased) of Gene_expression (biosynthesis) of thromboxane A2 in chest associated with angina
7) Confidence 0.01 Published 1991 Journal Am. J. Cardiol. Section Abstract Doc Link 1892067 Disease Relevance 0.78 Pain Relevance 0.54

General Comments

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