INT172441

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Context Info
Confidence 0.43
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.06
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rab27b) plasma membrane (Rab27b) GTPase activity (Rab27b)
cytoplasm (Rab27b)
Rab27b (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 4 52.92 Quite High
Serotonin 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 141 95.04 Very High Very High Very High
Syndrome 11 75.28 Quite High
Choroideremia 15 74.64 Quite High
Disease 6 59.44 Quite High
Piebaldism 3 17.20 Low Low
Anaphylaxis 10 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Retina Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Immunodeficiency 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our studies suggest that when Rab27b is absent, then Rab27a may partially compensate for its loss as a positive regulator of exocytosis, given that the secretory defect in the double KO cells is more severe than in the single Rab27b KO.
Negative_regulation (absent) of Rab27b associated with targeted disruption
1) Confidence 0.43 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.52 Pain Relevance 0.03
In addition, the dominant-negative approach could also result in inactivation of Rab27b activity, if not other related proteins.
Negative_regulation (inactivation) of Rab27b
2) Confidence 0.30 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.54 Pain Relevance 0

General Comments

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