INT172442

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Context Info
Confidence 0.37
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.50
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Anatomy Link Frequency
hepatocytes 1
mast cell 1
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 6 99.76 Very High Very High Very High
cytokine 1 77.32 Quite High
Inflammation 3 75.88 Quite High
fibrosis 8 74.24 Quite High
Paracetamol 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Bile 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nash(non-alcoholic Steatohepatitis) 7 99.80 Very High Very High Very High
Hepatitis Virus Infection 2 97.84 Very High Very High Very High
Targeted Disruption 155 85.44 High High
Hypersensitivity 6 84.08 Quite High
Gallstones 4 79.00 Quite High
INFLAMMATION 4 75.88 Quite High
Fibrosis 3 74.24 Quite High
Anaphylaxis 10 70.40 Quite High
Pressure And Volume Under Development 1 68.84 Quite High
Rhinitis 1 62.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The cells were then harvested, lysed and subjected to anti-Rab27a immunoprecipitations.
Rab27a Binding (immunoprecipitations) of
1) Confidence 0.37 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.28 Pain Relevance 0
These results suggest that Rab27b and to a lesser extent Rab27a are associated with serotonin-containing mast cell secretory granules.
Rab27a Binding (associated) of in mast cell associated with serotonin
2) Confidence 0.37 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.49 Pain Relevance 0.13
The disappearance of the keratin immunostaining in ballooned hepatocytes is reasonably specific for ASH and NASH, since it is not seen in ballooned cells of viral hepatitis or toxic damage and can therefore be used as an objective morphologic parameter in grading of steatohepatitis (Lackner et al. 2008).
ASH Binding (specific) of in hepatocytes associated with nash(non-alcoholic steatohepatitis) and hepatitis virus infection
3) Confidence 0.07 Published 2008 Journal Histochem Cell Biol Section Body Doc Link PMC2386529 Disease Relevance 0.73 Pain Relevance 0.08

General Comments

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