INT172445

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Context Info
Confidence 0.70
First Reported 2002
Last Reported 2011
Negated 1
Speculated 4
Reported most in Body
Documents 58
Total Number 62
Disease Relevance 39.62
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
hepatocytes 36
liver 26
fibroblasts 6
sebaceous gland 4
B cell 4
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 3 84.16 Quite High
cytokine 6 82.00 Quite High
imagery 62 72.48 Quite High
alcohol 86 67.80 Quite High
Central nervous system 48 66.48 Quite High
Inflammation 10 59.84 Quite High
fibrosis 13 43.48 Quite Low
dorsal root ganglion 37 10.00 Low Low
ketamine 46 5.00 Very Low Very Low Very Low
Pain 43 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Liver Cancer 453 100.00 Very High Very High Very High
Hepatocellular Cancer 1234 99.92 Very High Very High Very High
Targeted Disruption 1072 99.86 Very High Very High Very High
Hyperplasia 708 99.78 Very High Very High Very High
Cancer 4020 99.36 Very High Very High Very High
Epstein-barr Virus 58 99.32 Very High Very High Very High
Disease 48 99.08 Very High Very High Very High
Severe Combined Immunodeficiency 195 99.04 Very High Very High Very High
Hypertrophy 172 99.04 Very High Very High Very High
Colorectal Cancer 64 98.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that MYC overexpression results in rapid neoplastic conversion of neonatal hepatocytes.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes
1) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.54 Pain Relevance 0
After 2 weeks of MYC overexpression, no changes were observed in cell size compared to normal hepatocytes (Figure 8C and unpublished data).
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes
2) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
Overexpression of MYC is commonly associated with tumorigenesis.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of MYC
3) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.79 Pain Relevance 0
We examined the initial consequences of MYC overexpression in adult hepatocytes.
Spec (examined) Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes
4) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.18 Pain Relevance 0
To investigate if MYC overexpression is sufficient to induce HCC in our model system, we removed doxycycline treatment in adult mice (6–12 weeks of age) transgenic for both TRE-MYC and LAP-tTA.
Spec (investigate) Positive_regulation (overexpression) of Spec (investigate) Gene_expression (overexpression) of MYC associated with targeted disruption and hepatocellular cancer
5) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.84 Pain Relevance 0
Mice possessing either transgene alone did not overexpress MYC and lacked evidence of morbidity or mortality.
Neg (not) Positive_regulation (overexpress) of Neg (not) Gene_expression (overexpress) of MYC
6) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.68 Pain Relevance 0
Hence, MYC overexpression appears to induce cellular proliferation in neonatal hepatocytes that progresses rapidly to neoplasia.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes associated with cancer and hyperplasia
7) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.48 Pain Relevance 0
We conclude that MYC overexpression in adult hepatocytes results in the formation of highly malignant liver cancers with features consistent with human HCC.


Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in liver associated with liver cancer, malignant neoplastic disease and hepatocellular cancer
8) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.94 Pain Relevance 0
MYC overexpression caused HCC in adult mice less frequently than in neonates, and only after a prolonged latency.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC associated with hepatocellular cancer
9) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.54 Pain Relevance 0
We found that the ability of MYC overexpression to induce tumorigenesis in adult hepatocytes often requires the loss of p53 function.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes
10) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.85 Pain Relevance 0
MYC overexpression in human HCC is most commonly associated with genomic amplification (Abou-Elella et al. 1996; Kawate et al. 1999).
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC associated with hepatocellular cancer
11) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.57 Pain Relevance 0.03
Mice possessing both transgenes exhibited increased expression of the MYC transgene in their hepatocytes (Figure 1A).
Positive_regulation (increased) of Gene_expression (expression) of MYC in hepatocytes
12) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.63 Pain Relevance 0
We performed Ki67 immunofluorescence and DAPI staining in order to determine if MYC overexpression in neonatal livers was inducing hepatocyte proliferation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocyte
13) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.42 Pain Relevance 0
In contrast to the rapid neoplastic conversion we observed in embryonic or neonatal hepatocytes (Figures 4 and 5), MYC overexpression in adult hepatocytes caused a marked cellular growth, accompanied by an even greater relative nuclear growth, as observed by histological analysis (Figures 6–8).
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes
14) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
We were able to address this possibility directly by examining the consequences of MYC overexpression in adult hepatocytes after partial hepatectomy, which resulted in the immediate induction of adult hepatocyte proliferation associated with complete liver regeneration within 2 weeks.
Spec (examining) Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in liver
15) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.38 Pain Relevance 0
Therefore, MYC overexpression during embryonic development of the murine liver causes hepatocellular tumorigenesis within the first 10 d of birth (Figure 3).
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in liver
16) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.55 Pain Relevance 0
Mice that overexpressed MYC during embryonic development of the liver succumbed to neoplasia within 10 d of birth.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MYC in liver associated with cancer
17) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.64 Pain Relevance 0
When we examined the histology of the livers in which MYC was overexpressed during embryogenesis, we found that they resembled liver cancers (Figure 4B versus 4C) similar to the MYC-induced HCCs we observed in adult mice (see Figure 1C versus 4C).
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of MYC in liver associated with liver cancer
18) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.58 Pain Relevance 0
The effects of MYC overexpression on the size of adult hepatocytes depended on the duration of MYC activation.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC in hepatocytes
19) Confidence 0.70 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
In contrast, in adult mice MYC overexpression induced cell growth and DNA replication without mitotic cell division, and mice succumbed to neoplasia only after a prolonged latency.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MYC associated with cancer
20) Confidence 0.70 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.50 Pain Relevance 0

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