INT172449

Context Info Confidence 0.50 First Reported 2002 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.37 Pain Relevance 0.03

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a) GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)

Anatomy Link Frequency mast cell 2 Rab27a (Mus musculus)

Pain Link Frequency Relevance Heat Serotonin 6 56.88 cytokine 1 32.76 anesthesia 7 5.00 imagery 4 5.00 ketamine 3 5.00 Immobilon 3 5.00 Inflammatory mediators 2 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 325 99.86 Anaphylaxis 10 93.60 Cytomegalovirus Infection 6 84.96 Hypersensitivity 6 64.56 Choroideremia 45 44.08 Sprains And Strains 3 7.12 Syndrome 29 5.00 Disease 14 5.00 Retina Disease 12 5.00 Piebaldism 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Turn-over of Rab27a mutants

Positive_regulation (over) of Gene_expression (over) of Rab27a

1) Confidence 0.50 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.54 Pain Relevance 0

Turn-over of Rab27a mutants

Positive_regulation (over) of Gene_expression (mutants) of Rab27a

2) Confidence 0.50 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.54 Pain Relevance 0

Transgenic lines generated following injection of the PTyr/Rab27a/hGH or PCAG/myc-Rab27/?

Positive_regulation (generated) of Gene_expression (injection) of Rab27a associated with targeted disruption

3) Confidence 0.50 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.49 Pain Relevance 0

The results above suggested that both Rab27a and Rab27b expression was required for normal mast cell function, presumably in the control of regulated secretion.

Positive_regulation (required) of Gene_expression (expression) of Rab27a in mast cell

4) Confidence 0.50 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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