INT172449

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.37
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Anatomy Link Frequency
mast cell 2
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 6 56.88 Quite High
cytokine 1 32.76 Quite Low
anesthesia 7 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 325 99.86 Very High Very High Very High
Anaphylaxis 10 93.60 High High
Cytomegalovirus Infection 6 84.96 Quite High
Hypersensitivity 6 64.56 Quite High
Choroideremia 45 44.08 Quite Low
Sprains And Strains 3 7.12 Low Low
Syndrome 29 5.00 Very Low Very Low Very Low
Disease 14 5.00 Very Low Very Low Very Low
Retina Disease 12 5.00 Very Low Very Low Very Low
Piebaldism 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Turn-over of Rab27a mutants
Positive_regulation (over) of Gene_expression (over) of Rab27a
1) Confidence 0.50 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.54 Pain Relevance 0
Turn-over of Rab27a mutants
Positive_regulation (over) of Gene_expression (mutants) of Rab27a
2) Confidence 0.50 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.54 Pain Relevance 0
Transgenic lines generated following injection of the PTyr/Rab27a/hGH or PCAG/myc-Rab27/?
Positive_regulation (generated) of Gene_expression (injection) of Rab27a associated with targeted disruption
3) Confidence 0.50 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.49 Pain Relevance 0
The results above suggested that both Rab27a and Rab27b expression was required for normal mast cell function, presumably in the control of regulated secretion.
Positive_regulation (required) of Gene_expression (expression) of Rab27a in mast cell
4) Confidence 0.50 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.80 Pain Relevance 0.03

General Comments

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