INT172452

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2011
Negated 2
Speculated 2
Reported most in Body
Documents 121
Total Number 123
Disease Relevance 69.56
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
hepatocytes 22
liver 15
CPA 4
fibroblasts 3
pancreas 3
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 173 96.28 Very High Very High Very High
fibrosis 84 94.56 High High
mu opioid receptor 80 94.36 High High
Hippocampus 4 91.64 High High
isoflurane 22 89.32 High High
anesthesia 69 88.68 High High
Inflammation 41 88.68 High High
metalloproteinase 5 83.76 Quite High
cytokine 23 82.00 Quite High
dorsal root ganglion 111 77.56 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 2617 100.00 Very High Very High Very High
Liver Cancer 606 100.00 Very High Very High Very High
Hepatocellular Cancer 1546 99.92 Very High Very High Very High
Pancreatic Cancer 198 99.92 Very High Very High Very High
Cancer 7093 99.86 Very High Very High Very High
Residual Neoplasm 70 99.84 Very High Very High Very High
Coronary Heart Disease 65 99.84 Very High Very High Very High
Hyperplasia 896 99.78 Very High Very High Very High
Apoptosis 1619 99.46 Very High Very High Very High
Epstein-barr Virus 58 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the rapid neoplastic conversion we observed in embryonic or neonatal hepatocytes (Figures 4 and 5), MYC overexpression in adult hepatocytes caused a marked cellular growth, accompanied by an even greater relative nuclear growth, as observed by histological analysis (Figures 6–8).
Gene_expression (overexpression) of MYC in hepatocytes
1) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
Our results are consistent with reports that MYC overexpression can enforce DNA replication, resulting in endoreduplication in normal cells (Cerni et al. 1986; Mai et al. 1996; Chernova et al. 1998; Felsher et al. 2000).
Gene_expression (overexpression) of MYC
2) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.23 Pain Relevance 0
We performed Ki67 immunofluorescence and DAPI staining in order to determine if MYC overexpression in neonatal livers was inducing hepatocyte proliferation.
Gene_expression (overexpression) of MYC in hepatocyte
3) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.42 Pain Relevance 0
When we examined the histology of the livers in which MYC was overexpressed during embryogenesis, we found that they resembled liver cancers (Figure 4B versus 4C) similar to the MYC-induced HCCs we observed in adult mice (see Figure 1C versus 4C).
Gene_expression (overexpressed) of MYC in liver associated with liver cancer
4) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.58 Pain Relevance 0
We conclude that MYC overexpression in adult hepatocytes induces increased nuclear and cell growth, but not cell proliferation.
Gene_expression (overexpression) of MYC in hepatocytes
5) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.25 Pain Relevance 0
We conclude that MYC overexpression results in rapid neoplastic conversion of neonatal hepatocytes.
Gene_expression (overexpression) of MYC in hepatocytes
6) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.54 Pain Relevance 0
After 2 weeks of MYC overexpression, no changes were observed in cell size compared to normal hepatocytes (Figure 8C and unpublished data).
Gene_expression (overexpression) of MYC in hepatocytes
7) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
Mice that overexpressed MYC during embryonic development of the liver succumbed to neoplasia within 10 d of birth.
Gene_expression (overexpressed) of MYC in liver associated with cancer
8) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.64 Pain Relevance 0
To investigate if MYC overexpression is sufficient to induce HCC in our model system, we removed doxycycline treatment in adult mice (6–12 weeks of age) transgenic for both TRE-MYC and LAP-tTA.
Spec (investigate) Gene_expression (overexpression) of MYC associated with targeted disruption and hepatocellular cancer
9) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.84 Pain Relevance 0
Therefore, MYC overexpression during embryonic development of the murine liver causes hepatocellular tumorigenesis within the first 10 d of birth (Figure 3).
Gene_expression (overexpression) of MYC in liver
10) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.55 Pain Relevance 0
We did not observe increased Ki67 expression when MYC was overexpressed in the adult liver (Figure 6E and 6H versus 6D and 6G).
Gene_expression (overexpressed) of MYC in liver
11) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.16 Pain Relevance 0
Hence, MYC overexpression appears to induce cellular proliferation in neonatal hepatocytes that progresses rapidly to neoplasia.
Gene_expression (overexpression) of MYC in hepatocytes associated with cancer and hyperplasia
12) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.48 Pain Relevance 0
Thus, we have developed a transgenic model that enables us to conditionally regulate MYC expression in murine hepatocytes.
Gene_expression (expression) of MYC in hepatocytes associated with targeted disruption
13) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.86 Pain Relevance 0
Hence, tumorigenic conversion of hepatocytes was associated, in all age groups of mice, with further increases in the levels of MYC transgene expression.
Gene_expression (expression) of MYC in hepatocytes
14) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.43 Pain Relevance 0
The effects of MYC overexpression on the size of adult hepatocytes depended on the duration of MYC activation.
Gene_expression (overexpression) of MYC in hepatocytes
15) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.12 Pain Relevance 0
Mice possessing either transgene alone did not overexpress MYC and lacked evidence of morbidity or mortality.
Neg (not) Gene_expression (overexpress) of MYC
16) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.68 Pain Relevance 0
MYC overexpression in human HCC is most commonly associated with genomic amplification (Abou-Elella et al. 1996; Kawate et al. 1999).
Gene_expression (overexpression) of MYC associated with hepatocellular cancer
17) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 1.57 Pain Relevance 0.03
To address this hypothesis, we have used the tetracycline regulatory system to generate transgenic mice in which the expression of a c-MYC human transgene can be conditionally regulated in murine hepatocytes.
Gene_expression (expression) of MYC in hepatocytes associated with targeted disruption
18) Confidence 0.78 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.47 Pain Relevance 0
In contrast, in adult mice MYC overexpression induced cell growth and DNA replication without mitotic cell division, and mice succumbed to neoplasia only after a prolonged latency.
Gene_expression (overexpression) of MYC associated with cancer
19) Confidence 0.78 Published 2004 Journal PLoS Biology Section Abstract Doc Link PMC519000 Disease Relevance 0.50 Pain Relevance 0
We were able to address this possibility directly by examining the consequences of MYC overexpression in adult hepatocytes after partial hepatectomy, which resulted in the immediate induction of adult hepatocyte proliferation associated with complete liver regeneration within 2 weeks.
Gene_expression (overexpression) of MYC in liver
20) Confidence 0.78 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.38 Pain Relevance 0

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