INT172453

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Context Info
Confidence 0.48
First Reported 2002
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 6
Total Number 8
Disease Relevance 2.36
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Myc) DNA binding (Myc) protein complex (Myc)
cytoplasm (Myc) pigmentation (Myc) chromosome organization (Myc)
Anatomy Link Frequency
upper 1
Myc (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 37 85.84 High High
withdrawal 13 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Root ganglion neuron 1 5.00 Very Low Very Low Very Low
nociceptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 225 91.36 High High
Cytomegalovirus Infection 2 91.12 High High
Targeted Disruption 224 86.88 High High
Ganglion Cysts 39 85.84 High High
Liver Cancer 30 68.56 Quite High
Choroideremia 15 64.60 Quite High
Hyperplasia 51 64.56 Quite High
Alopecia 102 63.84 Quite High
Hepatocellular Cancer 84 58.84 Quite High
Malignant Neoplastic Disease 18 56.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To address this possibility, we examined total MYC protein levels by Western analysis using a polyclonal antibody that recognizes both the human c-MYC protein and the endogenous murine c-MYC (Figure 3B).
MYC Spec (examined) Binding (recognizes) of
1) Confidence 0.48 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.66 Pain Relevance 0
To address this possibility, we examined total MYC protein levels by Western analysis using a polyclonal antibody that recognizes both the human c-MYC protein and the endogenous murine c-MYC (Figure 3B).
MYC Spec (examined) Binding (recognizes) of
2) Confidence 0.42 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.66 Pain Relevance 0
The probe sequences for human c-MYC were forward primer 5?
MYC Binding (primer) of
3) Confidence 0.37 Published 2004 Journal PLoS Biology Section Body Doc Link PMC519000 Disease Relevance 0.07 Pain Relevance 0
To independently validate these findings, we prospectively scanned the promoter regions of TERT-regulated genes using TRANSFAC consensus binding sequences for both Myc and TCF/LEF.
Myc Binding (binding) of
4) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.17 Pain Relevance 0
However, Myc is already linked to the Wnt pathway by virtue of being an important transcriptional target of beta-catenin [54].
Myc Binding (linked) of
5) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.06 Pain Relevance 0
Myc is a potent oncogene that regulates gene expression by binding cognate DNA sequences as a heterodimer with a related protein Max [48].
Myc Binding (binding) of
6) Confidence 0.23 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2211538 Disease Relevance 0.08 Pain Relevance 0
Figure 1B provides a schematic diagram of the PCAG/myc-Rab27/?
myc Binding (diagram) of
7) Confidence 0.13 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.50 Pain Relevance 0
Anti-Myc immunoprecipitates were prepared from the cell lysates and immunoblotted with anti-pY (Fig. 4A, upper).
Anti-Myc Binding (immunoprecipitates) of in upper
8) Confidence 0.13 Published 2007 Journal BMC Dev Biol Section Body Doc Link PMC2217550 Disease Relevance 0.16 Pain Relevance 0.08

General Comments

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