INT172455

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Context Info
Confidence 1.00
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Immobilon 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 276 98.36 Very High Very High Very High
Choroideremia 45 90.12 High High
Retina Disease 12 88.40 High High
Syndrome 27 76.72 Quite High
Disease 12 74.04 Quite High
Piebaldism 6 68.72 Quite High
Immunodeficiency 3 58.80 Quite High
Cytomegalovirus Infection 6 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that dominant-negative Rab27a mutants are unstable and degrade rapidly in comparison with wild type Rab27a.


Protein_catabolism (degrade) of Rab27a
1) Confidence 1.00 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.53 Pain Relevance 0
Rapid degradation of dominant-negative Rab27 proteins in vivo precludes their use in transgenic mouse models

Background

Protein_catabolism (degradation) of Rab27 associated with targeted disruption
2) Confidence 0.66 Published 2002 Journal BMC Cell Biol Section Title Doc Link PMC137576 Disease Relevance 0.90 Pain Relevance 0
We found that dominant-negative Rab27 proteins are unstable and quickly degraded in vivo, and are thus unable to generate a dominant-interfering effect.


Protein_catabolism (degraded) of Rab27
3) Confidence 0.66 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.68 Pain Relevance 0

General Comments

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