INT172458

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Context Info
Confidence 0.53
First Reported 2001
Last Reported 2011
Negated 53
Speculated 3
Reported most in Body
Documents 155
Total Number 158
Disease Relevance 62.57
Pain Relevance 24.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Gopc) Golgi apparatus (Gopc) plasma membrane (Gopc)
cytoplasm (Gopc)
Anatomy Link Frequency
lung 5
neurons 4
heart 2
body 2
prefrontal 2
Gopc (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 314 100.00 Very High Very High Very High
qutenza 214 100.00 Very High Very High Very High
nMDA receptor 179 100.00 Very High Very High Very High
Glutamate 133 100.00 Very High Very High Very High
mu opioid receptor 66 100.00 Very High Very High Very High
Neuropeptide 53 100.00 Very High Very High Very High
painful pain 11 100.00 Very High Very High Very High
Antinociceptive 43 99.98 Very High Very High Very High
Morphine 211 99.60 Very High Very High Very High
Cannabinoid receptor 27 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1826 100.00 Very High Very High Very High
Targeted Disruption 1401 100.00 Very High Very High Very High
Stress 378 100.00 Very High Very High Very High
Anxiety Disorder 357 100.00 Very High Very High Very High
Pain 294 100.00 Very High Very High Very High
Body Weight 240 100.00 Very High Very High Very High
Shock 195 100.00 Very High Very High Very High
Mevalonate Kinase Deficiency 174 100.00 Very High Very High Very High
Depression 127 100.00 Very High Very High Very High
Cytomegalovirus Infection 100 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It appears that the contractility (Fig. 4) and duration (Fig. 5) which are dependent on efferent vagus activation are affected by gastric restraint, whereas the period (Fig. 6) is independent of efferent vagus activation.
Regulation (affected) of Fig
1) Confidence 0.53 Published 2010 Journal Obes Surg Section Body Doc Link PMC2950927 Disease Relevance 0.22 Pain Relevance 0.07
It appears that the contractility (Fig. 4) and duration (Fig. 5) which are dependent on efferent vagus activation are affected by gastric restraint, whereas the period (Fig. 6) is independent of efferent vagus activation.
Regulation (affected) of Fig
2) Confidence 0.53 Published 2010 Journal Obes Surg Section Body Doc Link PMC2950927 Disease Relevance 0.22 Pain Relevance 0.07
However, in 129S6 female and male mice, small but significant differences in paw withdrawal latency were observed between tail-biopsied and control mice (Fig. 2b).


Regulation (control) of Fig in tail associated with withdrawal
3) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714470 Disease Relevance 0.33 Pain Relevance 0.17
Alterations in anxiety-related behaviors in the elevated plus-maze test (Fig. 3)
Regulation (Alterations) of Fig associated with anxiety disorder
4) Confidence 0.39 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1473192 Disease Relevance 0.62 Pain Relevance 0.55
Alterations in stress-related depressive behaviors in the forced swimming test (Fig. 2)
Regulation (Alterations) of Fig associated with stress and depression
5) Confidence 0.39 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1473192 Disease Relevance 0.51 Pain Relevance 0.55
c-Fos statistical parametric mapping and more detailed laminar analyses revealed that the c-Fos-positive cell density was significantly greater in supragranular layers II and III of the barrel cortex in the test group than in the other control groups (Fig. 5B).
Regulation (control) of Fig in barrel cortex
6) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864740 Disease Relevance 0.17 Pain Relevance 0.18
The flip angle miscalibration will also inevitably affect the quantitative SNR measurements (Fig. 4), which were estimated to be in the order of 10% lower for LV myocardium and ?
Regulation (affect) of Fig in myocardium
7) Confidence 0.34 Published 2011 Journal Magnetic Resonance in Medicine Section Body Doc Link PMC3021721 Disease Relevance 0.06 Pain Relevance 0
When CCS was performed, the threshold at P1 was significantly lower (6.1 ± 0.4 g, n = 5) than in the control mice, but no significant change was observed at P5 or P12 (Fig. 1A).
Neg (no) Regulation (change) of Fig associated with stress
8) Confidence 0.32 Published 2008 Journal Mol Pain Section Body Doc Link PMC2596100 Disease Relevance 0.69 Pain Relevance 0.07
was significantly reduced, both in immunohistochemical and Western blotting analyses, in the cortex and hippocampus of lithium-treated 3-month-old TgCRND8 mice compared to saline-treated age-matched Tg controls (Fig. 7 G–K).
Regulation (controls) of Fig in hippocampus associated with targeted disruption and hippocampus
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3004858 Disease Relevance 0.54 Pain Relevance 0.16
30 mV, Fig. 8C) currents seemed unchanged by the superfusion with ghrelin (10 nM).
Neg (unchanged) Spec (seemed) Regulation (unchanged) of Fig
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2820089 Disease Relevance 0 Pain Relevance 0.24
Likewise, overdosed neonatal fos::luc mice showed expression in the brain that was visible through the skull (Fig. 1C) and was clearer after removal of the dorsal cranium (Fig 1D).
Regulation (visible) of Fig in skull
11) Confidence 0.28 Published 2003 Journal BMC Physiol Section Body Doc Link PMC194750 Disease Relevance 0.65 Pain Relevance 0.07
There was no difference in the number of neurons in GluR2-cKO mice compared with controls (Fig. 2L).
Regulation (controls) of Fig in neurons
12) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947514 Disease Relevance 0.25 Pain Relevance 0.23
To elucidate whether this binding was specifically due to the presentation of IQ-tag on the phage (Fig. 4A), we cloned the sequence encoding this peptide on the p7 coat proteins located on the opposite end of the phage.
Spec (whether) Regulation (due) of Fig
13) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1919420 Disease Relevance 0.07 Pain Relevance 0.04
5 follicles/mm in mice of both genotypes; n = 4 control and 3 K5-R1/R2 mice; Fig. 3 C).
Regulation (control) of Fig in follicles
14) Confidence 0.26 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.59 Pain Relevance 0.04
had no effect on HP (Fig.
Neg (no) Regulation (effect) of Fig
15) Confidence 0.26 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.28 Pain Relevance 0.04
0.02: Fig. 7C right panel, control, 17.7±4.0%; mutant, 2.9±1.2%; F1,8?
Regulation (control) of Fig
16) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2613534 Disease Relevance 0.38 Pain Relevance 0
In contrast, subcutaneous injections of Erufosine did not cause changes in body weight for all drug-concentrations used (Fig. 5).
Regulation (changes) of Fig in body associated with body weight
17) Confidence 0.24 Published 2009 Journal Radiat Oncol Section Body Doc Link PMC2773776 Disease Relevance 1.40 Pain Relevance 0.09
In situ hybridization studies indicated that P311 was abundantly expressed in the ACC as well as in other pain affection related regions of the brain (Fig. 1A, 1C, 1D, data not shown) [2,7].
Regulation (affection) of Fig in brain associated with pain and anterior cingulate cortex
18) Confidence 0.24 Published 2008 Journal Mol Pain Section Body Doc Link PMC2459156 Disease Relevance 0.29 Pain Relevance 0.65
1 receptor antagonists HP, HP-Met-I, and HP-Met-II (at the same doses that showed maximal antiallodynic effects) did not increase paw withdrawal latencies after stimulation with a filament at 4 g force, i.e., these drugs did not exert any antinociceptive effect on punctate mechanical nociceptive pain (Fig. 6, right panel).
Regulation (effect) of Fig in paw associated with antagonist, painful pain, antinociceptive, withdrawal and antiallodynic
19) Confidence 0.24 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2695546 Disease Relevance 0.10 Pain Relevance 1.04
Consistent with these results, PIP3 immunoreactivity was enhanced by MES treatment in insulin-stimulated HepG2 cells compared with sham-treated control (Fig. 8G).
Regulation (control) of Fig
20) Confidence 0.24 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2603588 Disease Relevance 0.25 Pain Relevance 0

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