INT172459

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Context Info
Confidence 0.75
First Reported 2002
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Rab27a) Golgi apparatus (Rab27a) intracellular (Rab27a)
GTPase activity (Rab27a) pigmentation (Rab27a) vesicle-mediated transport (Rab27a)
Anatomy Link Frequency
melanocytes 1
mast cell 1
hematopoietic cells 1
Rab27a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 6 36.96 Quite Low
Serotonin 18 30.92 Quite Low
imagery 12 15.56 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 239 91.52 High High
Immunodeficiency 4 86.48 High High
Piebaldism 5 83.80 Quite High
Syndrome 15 81.72 Quite High
Asthma 6 44.24 Quite Low
Disease 10 43.60 Quite Low
Hypersensitivity 18 43.24 Quite Low
INFLAMMATION 6 36.56 Quite Low
Leukemia 3 20.00 Low Low
Anaphylaxis 30 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Membranes were prehybridised and hybridised with Rab27a or Rab27b probe, corresponding to the entire Rab27 coding sequence, radiolabelled with 20 ?
Localization (sequence) of Rab27
1) Confidence 0.75 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.38 Pain Relevance 0
One surprising result obtained here was the increased secretory responses in BMMCs derived from Rab27aash/ash mice, raising the possibility that Rab27a and Rab27b might have distinct roles in mast cell secretion.
Localization (secretion) of Rab27a in mast cell
2) Confidence 0.75 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.46 Pain Relevance 0
The present evidence thus suggests that Rab27a acts as a positive regulator of regulated secretion in either conventional Golgi-derived granules in exocrine and endocrine cells, or lysosome-related organelles in hematopoietic cells and melanocytes (19,21,24).
Localization (secretion) of Rab27a in melanocytes
3) Confidence 0.75 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.36 Pain Relevance 0
The present evidence thus suggests that Rab27a acts as a positive regulator of regulated secretion in either conventional Golgi-derived granules in exocrine and endocrine cells, or lysosome-related organelles in hematopoietic cells and melanocytes (19,21,24).
Localization (secretion) of Rab27a in hematopoietic cells
4) Confidence 0.25 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.36 Pain Relevance 0

General Comments

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