INT172460

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.55
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Rab27b) plasma membrane (Rab27b) GTPase activity (Rab27b)
cytoplasm (Rab27b)
Rab27b (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 6 86.32 High High
imagery 4 35.28 Quite Low
anesthesia 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 141 99.18 Very High Very High Very High
Syndrome 11 80.88 Quite High
Piebaldism 3 80.64 Quite High
Anaphylaxis 10 64.52 Quite High
Disease 6 60.80 Quite High
Choroideremia 15 51.40 Quite High
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Retina Disease 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Immunodeficiency 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, in Rab27b KO or double KO BMMCs, the histamine-positive granules appeared more clustered (Figure 4) in a subset of BMMCs, more specifically 32% of Rab27b KO (n = 34) and 63% of double KO (n = 8) BMMCs, compared with no obvious accumulation of granules in wild-type (n = 55), Rab27a+/ash (n = 11), Rab27aash/ash (n = 36), Rab27b+/?
Neg (no) Positive_regulation (accumulation) of Rab27b associated with targeted disruption
1) Confidence 0.46 Published 2007 Journal Traffic (Copenhagen, Denmark) Section Body Doc Link PMC2063611 Disease Relevance 0.73 Pain Relevance 0.04
If the Rab27a mutant proteins Rab27aT23N and Rab27aN133I acted as strong dominant-negative mutants, as they do in cell culture [34,38], the transgenic lines generated should exhibit a phenotype resembling ashen mice, possibly with additional phenotypes due to inactivation of Rab27b as well.
Positive_regulation (inactivation) of Rab27b associated with targeted disruption
2) Confidence 0.35 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.82 Pain Relevance 0

General Comments

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