INT172463

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Context Info
Confidence 0.65
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 3.95
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (RAB27A) protein targeting (RAB27A) Golgi apparatus (RAB27A)
GTPase activity (RAB27A) lysosome (RAB27A)
Anatomy Link Frequency
HL-60 2
retina 1
vesicle 1
eosinophils 1
RAB27A (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 43 58.72 Quite High
beta blocker 4 48.16 Quite Low
cytokine 40 20.60 Low Low
Inflammation 121 13.28 Low Low
agonist 40 5.00 Very Low Very Low Very Low
complementary and alternative medicine 40 5.00 Very Low Very Low Very Low
corticosteroid 20 5.00 Very Low Very Low Very Low
Kinase C 16 5.00 Very Low Very Low Very Low
substance P 16 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 116 99.86 Very High Very High Very High
Choroideremia 347 97.68 Very High Very High Very High
Asthma 416 94.32 High High
Atherosclerosis 33 92.64 High High
Rhinitis 112 92.52 High High
Syndrome 43 85.04 High High
Piebaldism 6 84.08 Quite High
Immunodeficiency 7 83.24 Quite High
Li-fraumeni Syndrome 35 78.12 Quite High
Age-related Macular Degeneration 8 76.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transgenic mice (Rab27T23N, Rab27aQ78L and Rab27aWT) were crossed with ashen (ash/ash) on a C57BL/6J background obtained by repeated backcrossing of ash/+ mice (over five generations) with wild-type C57BL/6J mice [28].
Gene_expression (crossed) of Rab27 associated with targeted disruption
1) Confidence 0.65 Published 2002 Journal BMC Cell Biol Section Body Doc Link PMC137576 Disease Relevance 0.38 Pain Relevance 0
RAM-11 antibody (Dako North America, Inc., Carpinteria, CA, USA) was diluted 1:1000 and visualized using Horseradish Peroxidase ABC kit (Vector Laboratories, Burlingame, CA, USA) as per manufacturer's instructions.
Gene_expression (visualized) of RAM
2) Confidence 0.65 Published 2006 Journal BMC Nucl Med Section Body Doc Link PMC1479805 Disease Relevance 0.16 Pain Relevance 0.03
Only 10 Ensembl Gene Predictions fell within this region, including MYO5A, but not RAB27A (UCSC Genome Browser [9]).


Gene_expression (fell) of RAB27A
3) Confidence 0.48 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2855325 Disease Relevance 0.15 Pain Relevance 0
Rab27 is also present at high levels in the RPE and choriocapillaris and its under-prenylation could contribute to the degenerative process.
Gene_expression (present) of Rab27
4) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.84 Pain Relevance 0
Rab27A was also expressed in the HL-60 clone 15 "eosinophil-like" cell line but was not expressed in AML14.3D10 cells.
Neg (not) Gene_expression (expressed) of Rab27A in HL-60
5) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.35 Pain Relevance 0
Rab27A was also expressed in the HL-60 clone 15 "eosinophil-like" cell line but was not expressed in AML14.3D10 cells.
Gene_expression (expressed) of Rab27A in HL-60
6) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.35 Pain Relevance 0
Results: Rab27A was expressed in human peripheral blood eosinophils and transiently activated by secretory IgA stimulation.
Gene_expression (expressed) of Rab27A in eosinophils
7) Confidence 0.21 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.47 Pain Relevance 0
Interestingly, whereas Rab27 is also expressed in a variety of secretary and neuronal cells involved in synaptic transmission [19], [53], [54], [55], [56]; neuronal degeneration, outside the retina, has not been reported in CHM patients.
Gene_expression (expressed) of Rab27 in retina associated with choroideremia
8) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.75 Pain Relevance 0
We hypothesized that Rab27A is one of these GTP-binding proteins because, in other cells, it interacts with effectors that regulate vesicle motility, docking, and fusion.
Gene_expression (one) of Rab27A in vesicle
9) Confidence 0.18 Published 2007 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2875553 Disease Relevance 0.50 Pain Relevance 0

General Comments

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