INT172476

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.47
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
Anatomy Link Frequency
MDA-MB-231 1
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
vincristine 1 84.76 Quite High
peripheral neuropathy 2 76.60 Quite High
Bioavailability 1 50.92 Quite High
positron emission tomography 4 48.16 Quite Low
headache 4 29.52 Quite Low
cytokine 24 5.00 Very Low Very Low Very Low
Inflammation 24 5.00 Very Low Very Low Very Low
tolerance 20 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 316 98.16 Very High Very High Very High
Chronic Myeloid Leukemia 1 89.60 High High
Toxicity 42 88.64 High High
Skin Cancer 17 87.36 High High
Stress 72 80.76 Quite High
Thrombocytopenia 2 79.60 Quite High
Death 60 77.04 Quite High
Peripheral Neuropathy 3 76.60 Quite High
Anaemia 3 74.92 Quite High
Fatigue 9 74.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the Keap1 levels remained constant, oridonin enhanced the levels of Nrf2 protein in a dose-dependent manner, with the highest induction at 14 ?
Transcription (levels) of Nrf2 protein
1) Confidence 0.69 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.36 Pain Relevance 0
Compared with MDA-MB-231 cells (Figure 2B, lanes 2–7), UROtsa cells had a narrow range of Nrf2 induction, from 1.4 to 14?
Transcription (range) of Nrf2 in MDA-MB-231
2) Confidence 0.69 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.14 Pain Relevance 0
To demonstrate the specificity of antibody staining, we preincubated the anti-NRF2 antibody with NRF2 and luciferase in vitro transcribed and translated protein, respectively, for 30 min and then carried out immunohistochemical staining.


Transcription (transcribed) of NRF2
3) Confidence 0.51 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0 Pain Relevance 0
To demonstrate the specificity of antibody staining, we preincubated the anti-NRF2 antibody with NRF2 and luciferase in vitro transcribed and translated protein, respectively, for 30 min and then carried out immunohistochemical staining.


Transcription (transcribed) of NRF2
4) Confidence 0.51 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1584412 Disease Relevance 0 Pain Relevance 0
In addition, RTA 402 induces nuclear erythroid 2 p45 related factor (Nrf-2)-mediated transcription of antioxidant proteins which helps suppress tumor proliferation [35].
Transcription (transcription) of Nrf-2 associated with cancer
5) Confidence 0.37 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2647552 Disease Relevance 1.23 Pain Relevance 0.06
Several of these up regulated genes are engaged in transcription and translation regulation: transcription factor AP-4, transcriptional coactivator Pc4, Nrf2, EIF5 (Eukaryotic translation initiation factor 5), and PABPL1 (polyadenylate-binding protein 1).
Transcription (transcription) of Nrf2
6) Confidence 0.24 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0.06 Pain Relevance 0
The transcription factor Nrf2 mediates the up-regulation of ?
Transcription (transcription) of Nrf2
7) Confidence 0.10 Published 2006 Journal Theor Biol Med Model Section Body Doc Link PMC1508139 Disease Relevance 0.68 Pain Relevance 0.04

General Comments

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