INT172483

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Context Info
Confidence 0.44
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.33
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TFAP4) protein complex assembly (TFAP4) DNA binding (TFAP4)
TFAP4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 5.44 Low Low
Inflammation 3 5.08 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Opioid 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Peripheral nerve injury 1 5.00 Very Low Very Low Very Low
dorsal rhizotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Reticuloendotheliosis 1 88.64 High High
Cancer 43 62.72 Quite High
Neuroblastoma 50 57.36 Quite High
Nociception 2 57.36 Quite High
Pheochromocytoma 33 50.00 Quite Low
Death 1 40.76 Quite Low
Apoptosis 2 36.96 Quite Low
Demyelinating Disease 1 33.92 Quite Low
Shock 1 25.92 Quite Low
INFLAMMATION 3 5.08 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, we used the Oncomine (http://www.oncomine.org/) data analysis tool to interrogate gene expression data reported by Asgharzadeh et al. (2006) for 19 genes that were upregulated by demethylation but did not show detectable CpG methylation (SNN, RASD1, ARPC4, PTK2B, TFAP4, ZFP36L2, ARHGDIA, suppressor of lin-12-like (SEL1L), LTBP3, smoothelin (SMTH), ST3 ?
Positive_regulation (upregulated) of TFAP4
1) Confidence 0.44 Published 2008 Journal Endocrine-Related Cancer Section Body Doc Link PMC2519165 Disease Relevance 0.27 Pain Relevance 0
Several of these up regulated genes are engaged in transcription and translation regulation: transcription factor AP-4, transcriptional coactivator Pc4, Nrf2, EIF5 (Eukaryotic translation initiation factor 5), and PABPL1 (polyadenylate-binding protein 1).
Positive_regulation (engaged) of AP-4
2) Confidence 0.09 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0.06 Pain Relevance 0

General Comments

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