INT172487

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Context Info
Confidence 0.50
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.42
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 5 5.44 Low Low
Inflammation 4 5.08 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Lasting pain 3 5.00 Very Low Very Low Very Low
Acute pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Peripheral nerve injury 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
dorsal rhizotomy 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 15 88.64 High High
Death 19 71.20 Quite High
Nociception 2 57.36 Quite High
Apoptosis 18 36.96 Quite Low
Demyelinating Disease 1 33.92 Quite Low
INFLAMMATION 3 5.08 Very Low Very Low Very Low
Injury 16 5.00 Very Low Very Low Very Low
Pain 11 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Nervous System Injury 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the Keap1 levels remained constant, oridonin enhanced the levels of Nrf2 protein in a dose-dependent manner, with the highest induction at 14 ?
Positive_regulation (enhanced) of Transcription (levels) of Nrf2 protein
1) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.36 Pain Relevance 0
Several of these up regulated genes are engaged in transcription and translation regulation: transcription factor AP-4, transcriptional coactivator Pc4, Nrf2, EIF5 (Eukaryotic translation initiation factor 5), and PABPL1 (polyadenylate-binding protein 1).
Positive_regulation (engaged) of Transcription (transcription) of Nrf2
2) Confidence 0.18 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0.06 Pain Relevance 0

General Comments

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