INT172487

Context Info Confidence 0.50 First Reported 2002 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.42 Pain Relevance 0

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2) DNA binding (NFE2L2) cytoplasm (NFE2L2)

NFE2L2 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 5 5.44 Inflammation 4 5.08 Pain 6 5.00 Lasting pain 3 5.00 Acute pain 2 5.00 addiction 2 5.00 Analgesic 1 5.00 Peripheral nerve injury 1 5.00 Paracetamol 1 5.00 dorsal rhizotomy 1 5.00

Disease Link Frequency Relevance Heat Toxicity 15 88.64 Death 19 71.20 Nociception 2 57.36 Apoptosis 18 36.96 Demyelinating Disease 1 33.92 INFLAMMATION 3 5.08 Injury 16 5.00 Pain 11 5.00 Cancer 8 5.00 Nervous System Injury 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Although the Keap1 levels remained constant, oridonin enhanced the levels of Nrf2 protein in a dose-dependent manner, with the highest induction at 14 ?

Positive_regulation (enhanced) of Transcription (levels) of Nrf2 protein

1) Confidence 0.50 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.36 Pain Relevance 0

Several of these up regulated genes are engaged in transcription and translation regulation: transcription factor AP-4, transcriptional coactivator Pc4, Nrf2, EIF5 (Eukaryotic translation initiation factor 5), and PABPL1 (polyadenylate-binding protein 1).

Positive_regulation (engaged) of Transcription (transcription) of Nrf2

2) Confidence 0.18 Published 2002 Journal BMC Genomics Section Body Doc Link PMC137578 Disease Relevance 0.06 Pain Relevance 0

General Comments

This test has worked.