INT17250

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Context Info
Confidence 0.57
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 35
Total Number 36
Disease Relevance 21.00
Pain Relevance 8.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
osteoblasts 2
spinal 1
brain 1
urine 1
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 19 99.82 Very High Very High Very High
Endogenous opioid 6 99.52 Very High Very High Very High
antagonist 42 99.24 Very High Very High Very High
Enkephalin 10 99.24 Very High Very High Very High
opioid receptor 20 98.84 Very High Very High Very High
Opioid 10 98.80 Very High Very High Very High
5HT 282 98.58 Very High Very High Very High
narcan 182 98.12 Very High Very High Very High
agonist 53 98.00 Very High Very High Very High
Potency 27 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypercalcemia 155 99.96 Very High Very High Very High
Multiple Myeloma 52 99.84 Very High Very High Very High
Injury 15 99.74 Very High Very High Very High
Bone Disease 5 99.30 Very High Very High Very High
Osteoporosis 395 99.20 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 146 99.18 Very High Very High Very High
Respiratory Syncytial Virus 580 99.12 Very High Very High Very High
Disorder Of Lipid Metabolism 1 97.44 Very High Very High Very High
INFLAMMATION 44 97.20 Very High Very High Very High
Disorders Of Creatine Metabolism 6 96.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies associated with biochemical markers of bone metabolism and bone biopsy of therapy-naïve HIV-infected individuals show a significant decrease in osteocalcin, a marker of bone formation and a marked increase in C-telopeptide, a marker of bone resorption in a comparison with healthy HIV-seronegative controls.
Negative_regulation (decrease) of osteocalcin associated with acquired immune deficiency syndrome or hiv infection and hypercalcemia
1) Confidence 0.57 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 1.70 Pain Relevance 0.07
However, decreased serum osteocalcin levels and increased urinary excretion of bone resorption markers have been reported in patients under inhaled beclomethasone therapy.
Negative_regulation (decreased) of osteocalcin associated with hypercalcemia
2) Confidence 0.57 Published 1997 Journal Rev Rhum Engl Ed Section Abstract Doc Link 9178400 Disease Relevance 0.61 Pain Relevance 0.11
A study of bone samples from anti-retroviral therapy-naïve HIV infected subjects compared with healthy controls showed only decreased levels of osteocalcin in individuals with lower CD4 counts.
Negative_regulation (decreased) of osteocalcin associated with acquired immune deficiency syndrome or hiv infection
3) Confidence 0.57 Published 2004 Journal International Journal of Medical Sciences Section Body Doc Link PMC1074710 Disease Relevance 1.43 Pain Relevance 0.04
Morphine-induced osteocalcin inhibition was abolished when osteoblasts were incubated with naloxone.
Negative_regulation (inhibition) of osteocalcin in osteoblasts associated with narcan and morphine
4) Confidence 0.55 Published 2007 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1891106 Disease Relevance 0.16 Pain Relevance 0.62
Morphine-induced osteocalcin inhibition was abolished when osteoblasts were incubated concurrently with naloxone [10].
Negative_regulation (inhibition) of osteocalcin in osteoblasts associated with narcan and morphine
5) Confidence 0.55 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1891106 Disease Relevance 0.67 Pain Relevance 1.10
Stressful conditions are associated with decreased serum osteocalcin concentration.
Negative_regulation (decreased) of osteocalcin
6) Confidence 0.55 Published 2007 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC1891106 Disease Relevance 0.19 Pain Relevance 0.49
We have previously shown that several stressful situations associated with tissue injury determine a decrease in serum osteocalcin concentration.
Spec (determine) Negative_regulation (decrease) of osteocalcin associated with injury
7) Confidence 0.52 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.58 Pain Relevance 0.22
Morphine-induced osteocalcin inhibition was abolished when osteoblastic cells were incubated simultaneously with naloxone, whereas it was potentiated when cells were preincubated with naloxone.
Negative_regulation (inhibition) of osteocalcin associated with narcan, osteoporosis and morphine
8) Confidence 0.52 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.56 Pain Relevance 1.15
Endogenous opioids may be involved in the reduction of osteocalcin observed in stressful situations associated with tissue injury.
Negative_regulation (reduction) of osteocalcin associated with injury and endogenous opioid
9) Confidence 0.52 Published 2000 Journal Neuroendocrinology Section Abstract Doc Link 11025413 Disease Relevance 0.41 Pain Relevance 1.01
The urinary cross-linked N-terminal telopeptides of type I collagen and serum bone-specific alkaline phosphatase, osteocalcin, and undercarboxylated osteocalcin levels also markedly decreased.
Negative_regulation (decreased) of osteocalcin
10) Confidence 0.42 Published 2004 Journal Keio J Med Section Abstract Doc Link 15647630 Disease Relevance 0.60 Pain Relevance 0.25
The urinary cross-linked N-terminal telopeptides of type I collagen and serum bone-specific alkaline phosphatase, osteocalcin, and undercarboxylated osteocalcin levels also markedly decreased.
Negative_regulation (decreased) of osteocalcin
11) Confidence 0.42 Published 2004 Journal Keio J Med Section Abstract Doc Link 15647630 Disease Relevance 0.59 Pain Relevance 0.24
After L-T4 withdrawal, the clinical score significantly increased, as well as total cholesterol, triglycerides, creatine kinase, lactate dehydrogenase, aspartate aminotransferase and alanine aminotransferase, whereas SHBG, osteocalcin and urine hydroxyproline levels significantly decreased.
Negative_regulation (decreased) of osteocalcin in urine associated with withdrawal and disorder of lipid metabolism
12) Confidence 0.42 Published 2006 Journal J. Endocrinol. Invest. Section Abstract Doc Link 16553031 Disease Relevance 0.81 Pain Relevance 0.26
High turnover osteopathy markedly improved as indicated by declining levels of native osteocalcin (90+/-17 vs. 26+/-18 ng/ml), bone alkaline phosphatase (74+/-12 vs. 12+/-6 ng/ml), and carboxyterminal cross-linked telopeptide of type-I collagen (65+/-16 vs. 40+/-21 ng/ml) but increasing levels of carboxyterminal propeptide of type-I procollagen (120+/-36 vs. 148+/-41 ng/ml).
Negative_regulation (declining) of osteocalcin associated with bone disease
13) Confidence 0.42 Published 1999 Journal Miner Electrolyte Metab Section Abstract Doc Link 10436401 Disease Relevance 0.80 Pain Relevance 0.12
Over recent years, it has been shown that bortezomib, the first clinically approved proteasome inhibitor, may increase the markers of bone formation, bALP and osteocalcin, which are usually suppressed in MM.
Negative_regulation (suppressed) of osteocalcin associated with multiple myeloma
14) Confidence 0.42 Published 2010 Journal European Journal of Haematology Section Body Doc Link PMC2970902 Disease Relevance 0.77 Pain Relevance 0.04
Stressful conditions associated with tissue injury are associated with decreased serum osteocalcin concentration [8].
Negative_regulation (decreased) of osteocalcin associated with injury
15) Confidence 0.41 Published 2007 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1891106 Disease Relevance 0.77 Pain Relevance 0.46
Intact osteocalcin loss can be partially avoided by proteinase inhibitors and by incubating serum at 4 degrees C.
Negative_regulation (loss) of osteocalcin
16) Confidence 0.40 Published 1994 Journal J. Bone Miner. Res. Section Abstract Doc Link 8140939 Disease Relevance 0.76 Pain Relevance 0.08
The osteocalcin level measured with the two-site immunoradiometric assay specific for the intact molecule or with a conventional bovine RIA was rapidly decreased after incubation of serum at room temperature (-20 and -15%, respectively, after 3 h), whereas the total level of intact osteocalcin plus N-terminal midfragment was not changed.
Negative_regulation (decreased) of osteocalcin
17) Confidence 0.40 Published 1994 Journal J. Bone Miner. Res. Section Abstract Doc Link 8140939 Disease Relevance 0.92 Pain Relevance 0.10
At the ultrafiltration rate used, the OC haemofilter loss was small, 25 mg (?
Negative_regulation (loss) of OC
18) Confidence 0.35 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.43 Pain Relevance 0.06
During active treatment there was within the first month a dose-dependent decrease of the indices of bone resorption (fasting urinary calcium and hydroxyproline excretions), whereas only the higher dose and a treatment period of 4 months produced a reduction of bone formation (serum osteocalcin).
Negative_regulation (reduction) of osteocalcin associated with hypercalcemia
19) Confidence 0.35 Published 1991 Journal Calcif. Tissue Int. Section Abstract Doc Link 1893291 Disease Relevance 0.49 Pain Relevance 0.15
Her OC Cmin is 2.7 fold higher than the mean Cmin (1000 ng/ml) and slightly higher than the mean Cmax (2458 ng/ml) achieved after 500 mg bd of oseltamivir.[12] Given these high OC concentrations, and our knowledge that CVVH at the rate we used results in a small loss of OC via the filter, we could have given her standard dose oseltamivir and still seen viral clearance.
Negative_regulation (loss) of OC
20) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.27 Pain Relevance 0

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